112735-03-2

Basic information

• Product Name: 1,3-dimethyl-5-[(1-methylethyl)amino]pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
• CAS NO: 112735-03-2
• Molecular Formula: C₁₂H₁₆N₄O₂
• Molecular Weight: 248.281
• Mol File: 112735-03-2.mol

Chemical Properties

• Boiling Point: 431.1°C at 760 mmHg
• Flash Point: 214.5°C
• Density: 1.257g/cm³
• Vapor Pressure: 1.23E-07mmHg at 25°C
• Refractive Index: 1.6
• CAS DataBase Reference: 1,3-dimethyl-5-[(1-methylethyl)amino]pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-dimethyl-5-[(1-methylethyl)amino]pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione(112735-03-2)
• EPA Substance Registry System: 1,3-dimethyl-5-[(1-methylethyl)amino]pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione(112735-03-2)

Safety Data

• Hazardous Substances Data: 112735-03-2(Hazardous Substances Data)

Relevant articles and documents

Bronchodilating pyrido?2,3-d!pyrimidine derivatives

A rapid-acting remedy for asthma having a bronchodilating action contains at least one pyrido?2,3-d!pyrimidine derivative represented by the general formula (A) or pharmaceutically acceptable salts or metal complexes thereof as an effective component: STR1 wherein R1 and R2 are the same or different and each of R1 and R2 is hydrogen, alkyl or benzyl; R3 is hydrogen, hydroxyl, dialkylaminomethyleneamino or --NH--X; X is hydrogen, alkyl, alkenyl, hydroxyl, amino, hydroxyalkyl, benzyl or acyl; R4 is hydrogen, alkyl, halogen, nitro, amino, hydroxyl, benzyloxy, cyano, carboxyl, alkoxycarbonyl, alkoxysulfonyl, aminosulfonyl, dialkylaminosulfonyl or sulfo; and R5 is hydrogen, alkyl or amino. The rapid-acting remedy for bronchial asthma is capable of relieving the symptom of laboring breath at the onset of asthma due to its excellent bronchodilating action. It can be used as a therapy not only for allergic asthma but also for various bronchial asthmas such as endogenous asthma, exogenous asthma and dust asthma.

5-substituted pyrido[2,3-d]pyrimidine-2,4-diones

The present invention relates to a novel pyrido[2,3-d]pyrimidine derivative having the formula (I): STR1 wherein each of R1 and R2, which may be the same or different, is a lower alkyl group; and each of R3 and R4, which may be the same or different, is hydrogen, halogen, hydroxy, nitro, amino, hydroxyamino, hydrazino, azido, a lower alkenylamino group or a lower alkylamino group which may optionally have hydroxy; and pharmaceutically acceptable salt thereof. These compounds are useful as anti-allergic agents, for example, for the treatment of bronchial asthma, urticaria, allergic rhinitis, allergic dermatoses or allergic conjunctivitis.