112805-58-0 Usage
Uses
Used in Pharmaceutical Industry:
4-[(2S)-OxiranylMethoxy]benzenepropanoic Acid Methyl Ester is used as a chiral intermediate for the preparation of Esmolol hydrochloride optical isomers. This application is significant because Esmolol hydrochloride is a medication used to treat conditions such as tachycardia, hypertension, and certain types of arrhythmias. The chiral nature of this intermediate ensures that the final product has the desired stereochemistry, which is crucial for the drug's efficacy and safety.
Check Digit Verification of cas no
The CAS Registry Mumber 112805-58-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,8,0 and 5 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 112805-58:
(8*1)+(7*1)+(6*2)+(5*8)+(4*0)+(3*5)+(2*5)+(1*8)=100
100 % 10 = 0
So 112805-58-0 is a valid CAS Registry Number.
112805-58-0Relevant articles and documents
Novel asymmetric synthesis of (S)-esmolol using hydrolytic kinetic resolution
Narsaiah, A. Venkat,Kumar, J. Kranthi
experimental part, p. 1603 - 1608 (2011/06/27)
An efficient asymmetric synthesis of (S)-methyl 3-[4-[2-hydroxy-3- (isopropyl amino) propoxy] phenyl] propanoate is described. The key intermediate (S)-methyl 3-[4-(oxiran-2-ylmethoxy) phenyl] propanoate was obtained by hydrolytic kinetic resolution method using Jacobsen catalyst.
