- FUSED, SPIROCYCLIC HETEROAROMATIC COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS
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The present invention relates to compounds of Formula (I); to pharmaceutical1y acceptable salts thereof, to methods of using them to treat bacterial infections, and to methods for their preparation
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Page/Page column 99-100
(2010/04/30)
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- Difluoroalkylaromatics
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The present invention relates to 3,4-difluoro-2-alkylaromatics and 2,4-difluoro-3-alkylaromatics, to a process for their preparation and to their use for preparing active ingredients.
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Page/Page column 4; 5
(2010/02/11)
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- Process for making certain benzoic acid compounds
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The subject invention involves processes for making 2,4-difluoro-3-Q1-benzoic acid, wherein Q1 is derived from an electrophilic reagent, comprising the steps of: (a) treating 1-bromo-2,4-difluorobenzene with a strong, non-nucleophilic base; then treating
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Page column 11
(2010/01/30)
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- Antimicrobial quinolones, their compositions and uses
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This invention relates to novel antimicrobial compounds of formula; wherein X, R1, R3, R5, R6, and R8 are defined in the claims, and to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically-acceptable salts, hydrates, and biohydrolyzable esters, amides and imides thereof, and to compositions and uses of such compounds. The invention also relates to compounds derived from these compounds having antimicrobial uses.
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- 4-Hydroxy-quinoline-3-carboxylic
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A process for the preparation of a compound of the formula STR1 in which Y is a nitrile group, an ester group COOR1 or an acid amide CONR2 R3, R1, R2 and R3 each independently is hydrogen or C1 -C4 -alkyl, and R3 may also be phenyl, and X2, X3, X4 and X5 each independently is hydrogen, halogen, nitro, cyano, alkyl having 1-3 carbon atoms, alkoxy having 1-3 carbon atoms, alkylmercapto having 1-3 carbon atoms, alkylsulphonyl having 1-3 carbon atoms, or a phenylsulphonyl group which is optionally substituted in the aryl radical, comprising reacting an aminoacrylate of the formula in which X1 is halogen, a nitro group, an alkoxy, alkoxy, alkylmercapto or alkylsulphonyl group having 1-3 carbon atoms in each case, or an arylsulphonyl group, W is hydrogen or a --CH2 CH2 Z radical, Z is is a nitrile group, an ester group COOR4 or an acid amide group CONR5 R6, and R4, R5 and R6 each independently is hydrogen or C1 -C4 -alkyl, and R5 may also be phenyl, with an acid acceptor in an aprotic solvent. Some of the reactants are new, as are the products which are intermediates for antibacterially active 1-alkyl-4-quinolone-3-carboxylic acids.
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