- PROCESS FOR THE PREPARATION OF (ω -AMINOALKYLAMINO)ALKYL HALIDES AND CONVERSION TO AMIFOSTINE
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The present invention relates to processes for the preparation of (ω- aminoalkylainino)alkyl halides, their conversion to S-ω-(ω-aminoalkylamino)alkyl phosphothioates, and purification of the crystalline products of the reaction. The preparation process for the (ω-aminoalkylamino)alkyl halides comprises contacting an appropriate alcohol with a brominating agent in the presence of a sulfone solvent under temperature and pressure conditions suitable to effect salt formation without subsequent premature precipitation. The process is especially useful for converting (ω-aminoalkylamino)ethyl alcohol to amifostine.
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Page/Page column 15-16
(2008/06/13)
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- AMIFOSTINE DIHYDRATE CRYSTALLINE COMPOSITION
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The dihydrate of 2-(3-aminopropylamino)ethyl bromide dihydrobromide (amifostin as well as compositions containing this compound, methods of its production, and uses of th dihydrate of amifostine are described. The present disclosure relates in particular to the dihydrate of amifostine exhibiting radio-protectant, chemo-protectant, and cytoprotective activity, having therapeutic activity, in particular in oncology and cytotoxicology.
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Page/Page column 13-14
(2008/06/13)
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- NOVEL DIHYDRATE FORM OF AMIFOSTINE AND PROCESS FOR ITS PREPARATION
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The present invention relates to a novel dihydrate form of Amifostine of formula (I) and process for its preparation.
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Page/Page column 16; 17; 18
(2008/06/13)
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