- A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent
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A mild, chemoselective and sustainable biocatalysed synthesis of sulfoxides has been developed exploiting CALB and using AcOEt with a dual role of more environmentally friendly reaction solvent and enzyme substrate. A series of sulfoxides, including the drug omeprazole, have been synthesised in high yields and with excellent E-factors.
- Anselmi, Silvia,Liu, Siyu,Kim, Seong-Heun,Barry, Sarah M.,Moody, Thomas S.,Castagnolo, Daniele
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supporting information
p. 156 - 161
(2021/01/14)
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- Dibenzofuran heptabasic condensed ring unit and derivative, preparation method and application thereof
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The invention belongs to the technical field of organic optoelectronics, and discloses a dibenzofuran heptabasic condensed ring unit and a derivative, a preparation method and application thereof. Thechemical structural formula of the dibenzofuran heptabasic condensed ring unit is shown in general formula as shown in specification, in the formula, R1 is C1-30 alkyls, C3-30 cycloalkyls, C6-60 aromatic hydrocarbyls or C3-60 aromatic heterocyclyls; X is -C(R2)2-, -NR2-, -Si(R2)2-, -O-, -S-, -SO2- or -CO2-; and R2 is C1-30 alkyls, C3-30 cycloalkyls, C6-60 aromatic hydrocarbyls or C3-60 aromatic heterocyclyls. The invention further provides a derivative based on the dibenzofuran heptabasic condensed ring unit. The dibenzofuran heptabasic condensed ring and the derivative thereof effectively improve the fluorescence quantum yield and thermal stability, and a hole transfer property, and can be applied to preparation of an organic light-emitting diode light-emitting layer.
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Paragraph 0067; 0071-0072; 0080
(2019/01/23)
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- Kinetic investigation on the highly efficient and selective oxidation of sulfides to sulfoxides and sulfones with t-BuOOH catalyzed by La2O3
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The selective oxidation of various sulfides to sulfoxides by a simple, efficient, and environmentally benign method is of prime focus. In this paper, we have explored a highly efficient protocol for the oxidation of alkyl aryl sulfides to sulfoxides with high selectivities catalyzed by La2O3 in the presence of 70% t-BuOOH solution (water). We obtained predominantly the monooxygenated product. The over oxidation of sulfides to sulfones was not observed under these conditions. The resulting products are obtained in good to excellent yields within a reasonable time without the use of ligands and other additives. The epoxidation of the double bond as well as allylic oxidation are not observed with allyl sulfides. Sulfones can be obtained quantitatively by altering the reaction conditions. The surface morphology and the catalyst reusability were verified by XRD, AFM and SEM techniques. The surface area of the La2O3 was measured using BET isotherms.
- Mandal, Mrinmay,Chakraborty, Debashis
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p. 12111 - 12122
(2015/02/19)
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- Symmetric diarylsulfoxides as asymmetric sulfinylating reagents for dialkylmagnesium compounds
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At -78 °C, primary dialkylmagnesium compounds reacted with diarylsulfoxides when 1.5 equiv of the dilithium salt of (S)-BINOL was added as a promotor. Alkyl aryl sulfoxides resulted in up to quantitative yield and with up to 97% ee. This demonstrates the feasibility of asymmetric sulfinylations by achiral sulfinylating agents (from the perspective of Alkyl2Mg) as well as the feasibility of asymmetric sulfoxide-magnesium exchanges (from the perspective of Ar2SO).
- Ruppenthal, Simon,Brückner, Reinhard
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p. 897 - 910
(2015/01/30)
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