113049-35-7

Basic information

• Product Name: 1-(1-METHYL-1H-IMIDAZOL-2-YL)-PIPERAZINE
• Synonyms: 1-(1-METHYL-1H-IMIDAZOL-2-YL)-PIPERAZINE;Piperazine,1-(1-methyl-1H-imidazol-2-yl)-
• CAS NO: 113049-35-7
• Molecular Formula: C₈H₁₄N₄
• Molecular Weight: 166.22356
• Mol File: 113049-35-7.mol

Chemical Properties

• Boiling Point: 319.2±52.0 °C(Predicted)
• Appearance: /
• Density: 1.23±0.1 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 9.44±0.25(Predicted)
• CAS DataBase Reference: 1-(1-METHYL-1H-IMIDAZOL-2-YL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-METHYL-1H-IMIDAZOL-2-YL)-PIPERAZINE(113049-35-7)
• EPA Substance Registry System: 1-(1-METHYL-1H-IMIDAZOL-2-YL)-PIPERAZINE(113049-35-7)

Safety Data

• Hazardous Substances Data: 113049-35-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(1-METHYL-1H-IMIDAZOL-2-YL)-PIPERAZINE is used as a chemical intermediate for the synthesis of various pharmaceutical compounds, specifically in the creation of antihistamines and antipsychotics. Its role in binding to receptors in the central nervous system aids in the development of drugs that address neurological disorders.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 1-(1-METHYL-1H-IMIDAZOL-2-YL)-PIPERAZINE is utilized for its potential antifungal and antiparasitic properties. This makes it a compound of interest for research into new treatments and therapies for fungal and parasitic infections.

Upstream product

• 110-85-0 piperazine 
• 16681-59-7 2-bromo-1-methyl-1H-imidazole 

Downstream Products

• 1117922-90-3 2-chloro-4-(4-fluorophenyl)-6-(4-(1-methyl-1H-imidazol-2-yl)-piperazin-1-yl)-pyrimidine 
• 1117949-04-8 2-chloro-4-(3-chloro-4-fluorophenyl)-6-(4-(1-methyl-1H-imidazol-2-yl)-piperazin-1-yl)-pyrimidine 
• 943326-02-1 1-(3-phenyl-propiolyl)-4-(1-methyl-imidazol-2-yl)-piperazine 

Relevant articles and documents

Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and in Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model

A series of 2,4-disubstituted imidazopyridines, originating from a SoftFocus Kinase library, was identified from a high throughput phenotypic screen against the human malaria parasite Plasmodium falciparum. Hit compounds showed moderate asexual blood stage activity. During lead optimization, several issues were flagged such as cross-resistance against the multidrug-resistant K1 strain, in vitro cytotoxicity, and cardiotoxicity and were addressed through structure-Activity and structure-property relationship studies. Pharmacokinetic properties were assessed in mice for compounds showing desirable in vitro activity, a selectivity window over cytotoxicity, and microsomal metabolic stability. Frontrunner compound 37 showed good exposure in mice combined with good in vitro activity against the malaria parasite, which translated into in vivo efficacy in the P. falciparum NOD-scid IL-2Rnull (NSG) mouse model. Preliminary mechanistic studies suggest inhibition of hemozoin formation as a contributing mode of action.

Substituted propiolic acid amides and their use for producing drugs

The present invention relates to substituted propiolic acid amides, methods for the production thereof, medicaments containing these compounds and the use thereof for producing medicaments.

Piperazinyl-substituted pyridine and imidazole anti-arrhythmic agents

A series of novel 4-substituted piperazinyl-pyridine and 4-substituted piperazinyl-imidazole compounds have been prepared, including their pharmaceutically acceptable salts, wherein the 4-substituent is a lower phenylalkyl group or a derivative thereof further substituted on the phenyl moiety by a sulphamoyl or sulphonylamino group or by a nitro, amino or acetamido group. These particular compounds are useful in therapy as highly effective anti-arrhythmic agents and therefore, are of value in the treatment of various cardiac arrythmias. The most preferred member compound of the series is N-{4-[1-hydroxy-2-(4-[4-pyridinyl]-1-piperazinyl)ethyl]phenyl} methanesulphonamide. Methods for preparing all these compounds from known starting materials are provided.