Structure-activity relationships of antitubercular nitroimidazoles. 1. structural features associated with aerobic and anaerobic activities of 4 - And 5-nitroimidazoles
The 4-nitroimidazole PA-824 is active against aerobic and anaerobic Mycobacterium tuberculosis(Mtb)while 5-nitroimidazoles like metronidazole are active against only anaerobic Mtb. We have synthesized analogues of both 4 - and 5-nitroimidazoles and explor
Kim, Pilho,Zhang, Liang,Manjunatha, Ujjini H.,Singh, Ramandeep,Patel, Sejal,Jiricek, Jan,Keller, Thomas H.,Boshoff, Helena I.,Barry III, Clifton E.,Dowd, Cynthia S.
experimental part
p. 1317 - 1328
(2009/12/07)
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