113162-46-2Relevant articles and documents
Diarylsulfonylureas for use in treating secretory diarrhea
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, (2008/06/13)
This invention provides methods of treating secretory diarrhea or cystic fibrosis in a mammal which comprises administering to a mammal in need thereof an effective amount of diarylsulfonylurea. This invention also describes specific diarylsulfonylureas f
Antitumor compositions and methods of treatment
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, (2008/06/13)
This invention provides certain sulfonamidoquinoxaline derivatives and methods for using them in the treatment of susceptible neoplasms in mammals. Also provided are certain novel pharmaceutical formulations employing these sulfonamidoquinoxaline derivatives, in combination with a carrier, diluent or excipient.
Indole-sulfonamides as antitumor agents
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, (2008/06/13)
This invention provides certain indolinesulfonamide and substituted-indolesulfonamide derivatives of the formula wherein: R1 is C1-C6 alkyl;, R2 and R3 are independently selected from the group consisting of hydrogen, halo, C1-C6 alkyl, and trifluoromethyl, provided that no more than one of R2 and R3 can be hydrogen;, and methods for using them in the treatment of susceptible neoplasms in mammals. Also provided are certain novel pharmaceutical formulations employing these indolinesulfonamide and substituted-indolesulfonamide derivatives in combination with a carrier, excipient or diluent, as well as processes for preparing the compounds.
Antitumor compositions and methods of treatment
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, (2008/06/13)
This invention provides the use of certain tetra-substituted imidazolidin-2-one derivatives in the treatment of susceptible neoplasms in mammals. Also provided are certain novel tetra-substituted imidazolidin-2-one derivatives and pharmaceutical formulati
Regioselectivity of Electrophilic Aromatic Substitution: Syntheses of 6- and 7-Sulfamoylindolines and -indoles
Borror, Alan L.,Chinoporos, Efthimios,Filosa, Michael P.,Herchen, Stephen R.,Petersen, Cheryl Pizzo,Stern, Carol A.
, p. 2047 - 2052 (2007/10/02)
The previously reported chlorosulfonation of 1-acetyl-5-bromoindoline at the 7-position is in error.In actuality, the 6-substituted product is the sole regioisomer produced.This regiochemical assignment is based on NMR data and confirmed by X-ray analysis.We have prepared the first 7-sulfamoylindoline and the corresponding indole from indoline using the indoline nitrogen to direct sulfamoylation intarmolecularly to the 7-position.The new 7-substituted derivatives may prove to be important as intermediates to indole-based dyes and as herbicides.
Color transfer photographic processes and products with indole phthalein filter dyes
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, (2008/06/13)
This invention relates to diffusion transfer photographic processes adapted to be performed in the presence of ambient light and to diffusion transfer products useful in such processes wherein enhanced opacification particularly, in the green region of the visible spectrum is achieved by employing a 7-sulfonamido/5- or 6-sulfamoyl indole phthalein as the light-absorbing, pH-sensitive optical filter agent for the shorter wavelength region of the visible spectrum.