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1,2,3,6-TETRAHYDRO-1-METHYL-4-(2,4,6-TRIMETHOXYPHENYL)-PYRIDINE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

113225-07-3

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113225-07-3 Usage

Tetrahydropyridine ring

A six-membered nitrogen-containing ring with four saturated carbon atoms.

Tetrahydropyridine ring

Provides a specific structural framework for potential medicinal properties.

1-methyl group

A methyl group (CH3) attached to the tetrahydropyridine ring at the first position.

4-(2,4,6-trimethoxyphenyl) group

A phenyl ring with three methoxy groups (-OCH3) attached at the 2nd, 4th, and 6th positions, connected to the tetrahydropyridine ring at the 4th position.

Derivative of

Pyridine

Industry application

Pharmaceutical industry

Potential use

Drug candidate for the treatment of various conditions

Multiple methoxy groups

Confer unique electronic and steric properties to the molecule, which may influence its biological activity.

Ongoing research

Exploring potential applications in the field of medicine

Medicinal properties

Attracting attention due to potential therapeutic effects (specific conditions not mentioned in the material provided)

Check Digit Verification of cas no

The CAS Registry Mumber 113225-07-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,2,2 and 5 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 113225-07:
(8*1)+(7*1)+(6*3)+(5*2)+(4*2)+(3*5)+(2*0)+(1*7)=73
73 % 10 = 3
So 113225-07-3 is a valid CAS Registry Number.
InChI:InChI=1/C15H21NO3/c1-16-7-5-11(6-8-16)15-13(18-3)9-12(17-2)10-14(15)19-4/h5,9-10H,6-8H2,1-4H3

113225-07-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-methyl-4-(2,4,6-trimethoxyphenyl)-3,6-dihydro-2H-pyridine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:113225-07-3 SDS

113225-07-3Relevant articles and documents

Piperidinyl-embeded chalcones possessing anti PI3Kδ inhibitory properties exhibit anti-atopic properties in preclinical models

Dumontet, Charles,Beck, Guillaume,Gardebien, Fabrice,Haudecoeur, Romain,Mathé, Doriane,Matera, Eva-Laure,Tourette, Anne,Mattei, Eve,Esmenjaud, Justine,Boyère, Cédric,Nurisso, Alessandra,Peuchmaur, Marine,Pérès, Basile,Bouchaud, Grégory,Magnan, Antoine,Monneret, Guillaume,Boumendjel, Ahcène

, p. 405 - 413 (2018/09/22)

Phosphatidylinositide 3-kinases (PI3Ks) are widely expressed enzymes involved in membrane signalization pathways. Attempts to administer inhibitors with broad activity against different isoforms have failed due to toxicity. Conversely the PI3Kδ isoform is

PYRROLIDINE-SUBSTITUTED FLAVONES AS RADIO-SENSITIZERS FOR USE IN THE TREATMENT OF CANCER

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Paragraph 0053-054, (2016/09/12)

The present invention relates to a combination for the treatment of cancer wherein the combination exhibits a synergistic effect. The combination comprises radiation and at least one cyclin dependent kinase (CDK) inhibitor selected from the compounds of f

Synthesis of newer piperidinyl chalcones and their anticancer activity in human cancer cell lines

Jayashree,Patel, Harshkumar H.,Mathew, Neethu Susan,Nayak, Yogendra

, p. 3673 - 3688 (2016/04/05)

Newer tetrahydropyridine chalcones were synthesized and tested for their antioxidant and anticancer activity. These molecules showed significant anticancer activity at IC50 50 μM in human cancer cell lines such as A549 (lung adenocarcinoma),

AN IMPROVED PROCESS FOR PREPARATION OF AN INTERMEDIATE OF THE PYRROLIDINE SUBSTITUTED FLAVONES

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Page/Page column 17, (2014/09/03)

The present invention relates to a process for the preparation of a key intermediate (as described herein) used in the synthesis of (+)-trans enantiomer of pyrrolidine substituted flavones, represented by the compounds of formula (1) or pharmaceutically a

A PROCESS FOR PREPARATION OF AN INTERMEDIATE OF THE PYRROLIDINE SUBSTITUTED FLAVONES

-

Page/Page column 16, (2014/09/03)

The present invention relates to a process for the preparation of a key intermediate (as described herein) used in the synthesis of (+)-trans enantiomer of pyrrolidine substituted flavones, represented by the compounds of formula (1) or pharmaceutically a

Synthesis and antioxidant, cytotoxicity and antimicrobial activities of novel curcumin mimics

Bandgar, Babasaheb P.,Jalde, Shivkumar S.,Korbad, Balaji L.,Patil, Sachin A.,Chavan, Hemant V.,Kinkar, Santosh N.,Adsul, Laxman K.,Shringare, Sadanand N.,Nile, Shivraj H.

scheme or table, p. 267 - 274 (2012/07/13)

Claisen-Schmidt condensation of 3-(1,2,3,6-tetrahydro-1-methylpyridin-4-yl) -2,4,5-trimethoxybenzaldehyde 3 and various aromatic, heterocyclic and alicyclic amides of 3-aminoacetophenone 6(as) afforded novel curcumin mimics. All the synthesized compounds

CYTOKINE INHIBITORS

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Page/Page column 37-38, (2011/10/13)

The present invention provides compounds represented by general formula (I): wherein, R1; R2, R3, L and T are as defined in the specification, in all their stereoisomeric and tautomeric forms and mixtures thereof in all ratios, and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, and prodrugs thereof. The invention also relates to processes for the manufacture of compounds of formula (I) and pharmaceutical compositions containing them. The compounds and the pharmaceutical compositions of the present invention are useful in the treatment of a condition or disorder mediated by one or more cytokines selected from Tumor Necrosis Factor-alpha (TNF-oc) and interleukins such as IL-1, IL-6, and IL-8. The present invention further provides a method of treatment of inflammatory disorders by administering a therapeutically effective amount of the said compound of formula (I) or its pharmaceutical composition, to a mammal in need thereof.

NOVEL ENANTIOMERICALLY PURE COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS

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Page/Page column 12, (2010/08/03)

The present invention relates to an enantiomerically pure (+)-trans-enantiomer of a compound represented by the following formula (I): wherein R1, R2, R3, R4 and R9 are as defined in the specification; enantiomerically pure intermediates thereof, to processes for the preparation of the enantiomerically pure compound and its intermediates, and to a pharmaceutical composition comprising the enantiomerically pure compound. The compound of formula (I) is useful for the treatment of diseases or disorders mediated by the inhibition of cyclin dependant kinase, such as cancer.

COMPOUNDS AND COMPOSITIONS COMPRISING CDK INHIBITORS AND METHODS FOR THE TREATMENT OF CANCER

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Page/Page column 30-31, (2010/11/18)

Disclosed herein are compounds suitable for use as antitumor agents, methods for treating cancer wherein the disclosed compounds are used in making a medicament for the treatment of cancer, methods for treating a tumor comprising, administering to a subject a composition comprising one or more of the disclosed cytotoxic agents, and methods for preparing the disclosed antitumor agents.

ENANTIOMERICALLY PURE FLAVONE DERIVATIVES FOR THE TREATMENT OF POLIFERATIVE DISORDERS AND PROCESSES FOR THEIR PREPARATION

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Page/Page column 35, (2008/06/13)

The present invention relates to an enantiomerically pure (+)-trans-enantiomer of a compound represented by the following formula (I): wherein R1, R2, R3, R4 and R9 are as defined in the specification; enantiomerically pure intermediates thereof, to processes for the preparation of the enantiomerically pure compound and its intermediates, and to a pharmaceutical composition comprising the enantiomerically pure compound. The compound of formula (I) is useful for the treatment of diseases or disorders mediated by the inhibition of cyclin dependant kinase, such as cancer.

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