1133378-37-6

Basic information

• Product Name: Darunavir-D9
• Synonyms: Darunavir-D9;[(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl-d9)amino]-2-hydroxy-1-(phenyl-methyl)propyl]carabamic Acid (3R,3aS,6aR)-Hexahydrofuro[2,3-b]-furan-3-yl Ester;TMC-114-d9;UIC-94017-d9;[(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl-d9)amino]-2-hydroxy-1-(phenyl-methyl)propyl]carabamic Acid (3R,3aS,6aR)-Hexahydrofuro[2,3-β]-furan-3-yl Ester;Darunavir-d9
• CAS NO: 1133378-37-6
• Molecular Formula: C₂₇H₃₇N₃O₇S
• Molecular Weight: 547.66358
• Product Categories: Intermediates & Fine Chemicals;Isotope Labeled Compounds;Pharmaceuticals;Aromatics;Heterocycles;Inhibitors;Isotope Labelled Compounds
• Mol File: 1133378-37-6.mol

Chemical Properties

• Melting Point: 74-760C
• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Darunavir-D9(CAS DataBase Reference)
• NIST Chemistry Reference: Darunavir-D9(1133378-37-6)
• EPA Substance Registry System: Darunavir-D9(1133378-37-6)

Safety Data

• Hazardous Substances Data: 1133378-37-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Darunavir-D9 is used as a second-generation HIV-1 protease inhibitor for the treatment of HIV. It is effective against HIV-1LAI in MT-2 cells, wild-type, and multidrug-resistant clinical isolates of HIV-1 in phytohemagglutinin-activated peripheral blood mononuclear cells (PHA-PBMCs). It also inhibits cell-free diffusion and cell-to-cell spread of HIV-1 in Jurkat cell populations.
Used in Analytical Chemistry:
Darunavir-D9 is used as an internal standard for the quantification of darunavir by GCor LC-mass spectrometry, which helps in the accurate measurement and analysis of darunavir in various formulations and samples.
Used in Antiviral Research:
Darunavir-D9 is involved in COVID-19-related research, contributing to the understanding of the virus and the development of potential antiviral treatments.

Upstream product

• 1146967-60-3 4-amino-N-((2S,3R))-3-amino-2-hydroxy-4-phenylbutyl-N-(isobutyl-d9)-benzenesulfonamide 
• 253265-97-3 1-[[[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl]oxy]pyrrolidine-2,5-dione 

Relevant articles and documents

DEUTERATED DARUNAVIR

This invention relates to novel compounds that are hydroxyethylamino sulfonamide derivatives and pharmaceutically acceptable salts thereof. More specifically, this invention relates to novel hydroxyethylamino sulfonamide derivatives that are derivatives o