Synthesis and biological activity of 1 β-methyl-2-[5'-isoxazoloethenylpyrrolidin-3'-ylthio]carbapenems
A new series of 1β-methylcarbapenems 1a-i bearing isoxazoloethenyl groups on the pyrrolidine ring has been prepared and evaluated for in vitro antibacterial activity and stability to DHP-I. Most compounds showed excellent antibacterial activity and high s
Kim, Dong Jin,Seo, Kyung Jae,Lee, Kyung Seok,Shin, Kye Jung,Yoo, Kyung Ho,Kim, Dong Chan,Park, Sang Woo
Synthesis, biological evaluation, and structure-activity relationships for 5-[(E)-2-arylethenyl]-3-isoxazolecarboxylic acid alkyl ester derivatives as valuable antitubercular chemotypes
Tuberculosis (TB), mostly caused by Mycobacterium tuberculosis (Mtb), is one of the leading causes of death from infectious disease worldwide. Its coinfection with HIV and the emergence of multidrugresistant TB(MDR-TB) and extensively drug-resistant TB (X
Pieroni, Marco,Lilienkampf, Annamaria,Baojie, Wan,Yuehong, Wang,Franzblau, Scott G.,Kozikowski, Alan P.
scheme or table
p. 6287 - 6296
(2010/03/24)
Synthesis and evaluation of 2β-oxyimino and alkenylpenicillanic acid sulfone derivatives as β-lactamase inhibitors
The synthesis and in vitro synergies of 2β-alkenyl and oxyiminopenam sulfone derivatives are described. Most of the compounds synthesized exhibited good inhibitory activities and synergistic antibacterial activities with piperacillin and ceftriaxone, resp
Cho, Yong Seo,Ha, Young Jin,Kwon, Jin Sun,Pae, Ae Nim,Choi, Kyung Il,Koh, Hun Yeong,Chang, Moon Ho,Yoon, Cheol-Min,Lee, Gwan Sun
p. 7 - 12
(2007/10/03)
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