- Studies on Condensed Heterocyclic Compounds XVI. Synthesis of 3-Alkyl-6-(2,4-Dichlorophenoxymethyl)-s-Triazolo[3,4-b]-1,3,4-Thiadiazoles and 6,6′-Bis(3-Aryl-s-Triazolo[3,4-b]-1,3,4-Thiadiazoles)
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Several 3-alkyl-6-(2,4-dichlorophenoxymethyl)-s-triazolo[3,4-b]-1,3,4-thiadiazoles 3a-3e and 6,6′-bis(3-aryl-s-triazolo[3,4-b]-1,3,4-thiadiazoles) 3f-3j were synthesized. The structures of all the compounds synthesized were elucidated by elemental analyses and spectral data The representative compounds 3a and 3b exhibited moderate biological activities.
- Zhang, Zi-Yi,Sun, Xiao-Wen,Chu, Chang-Hu,Zhao, Lan
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p. 535 - 538
(2007/10/03)
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- Synthesis of Heterocycles. Part VII . Synthesis and Antimicrobial Activity of Some 7H-s-Triazolothiadiazine and s-Triazolothiadiazole Derivatives
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The cyclization of 4-amino-5-aryl-3-cyanomethylthio-1,2,4-triazoles II in the presence of concentrated sulfuric acid yields 7H-6-amino-s-triazolothiadiazines III.Cyclization of 4-amino-5-aryl-1,2,4-triazole-3-thiones I with phenacyl chloride yields 7H-3-aryl-6-phenyl-s-triazolothiadiazines IV.Similarly, compounds I condensed with cyanogen bromide, phenyl isothiocyanate and carbon disulfide to give the corresponding cyclized products 6-amino-3-aryl-s-triazolothiadiazoles V, 3-aryl-6-phenylamino-s-triazolothiadiazoles VI and 3-aryl-s-triazolothiadiazol-6(5H)thiones VII, respectively.Also in the presence of phosphoryl chloride, compounds I underwent cyclization with monocarboxylic acids and oxalic acid to 3,6-diaryl-s-triazolothiadiazole VIII and 6,6'-bis(3-aryl-s-triazolothiadiazoles) IX.The above compounds were screened for their antimicrobial activity.
- Eweiss, N. F.,Bahajaj, A. A.
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p. 1173 - 1182
(2007/10/02)
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