Synthesis of Chiral Sulfoxides via Pd(II)-Catalyzed Enantioselective C-H Alkynylation/Kinetic Resolution of 2-(Arylsulfinyl)pyridines
A Pd(II)-catalyzed enantioselective C-H alkynylation of 2-(arylsulfinyl)pyridines via kinetic resolution using cheap and commercially available l-pGlu-OH as a chiral ligand is reported. A wide range of 2-(arylsulfinyl)pyridines were compatible with this p
A NEW AND CONVENIENT PROCESS FOR PREPARATION OF OPTICALLY PURE ARYL 2-PYRIDYL SULFOXIDES
α-Lithiation of aryl 2-pyridyl sulfoxides, treatment with l-menthyl sulfinate, and desulfinylation with Grignard reagents gave optically pure aryl 2-pyridyl sulfoxides in moderate yields.