Esters of N-(9-Fluorenylmethoxycarbonyl) Amino Acids with 4-Hydroxy-3-oxo-2,5-diphenyl-2,3-dihydrothiophene 1,1-Dioxide (Fmoc-Amino Acid TDO Esters) and Their Use in Solid Phase Peptide Synthesis
Fmoc-Amino acid TDO esters 3 are prepared by reaction of Fmoc-amino acids 1 with the cyclic carbonate 2.Their application in peptide synthesis is demonstrated by the preparation of leucylalanylvalylglycine (7) at a p-alkoxybenzyl alcohol resin.
Kirstgen, Reinhard,Olbrich, Alfred,Rehwinkel, Hartmut,Steglich, Wolfgang
p. 437 - 440
(2007/10/02)
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