One-pot three-component reaction between 2-aminopyridines, aldehydes and Meldrum's acid in water: An efficient synthesis of β-amino acids
A novel, one-pot, three-component synthesis of β-amino acids is described. Heating an alkaline aqueous solution of a 2-aminopyridine, an aldehyde and Meldrum's acid afforded β-amino acids in good to excellent yields. Georg Thieme Verlag Stuttgart.