113556-37-9Relevant academic research and scientific papers
SYNTHESIS OF 4-ALLYL-4-ARYLAMINOPIPERIDINES AND THEIR TRANSFORMATIONS TO SPIRO
Prostakov, N. S.,Kuznetsov, V. V.,Stashenko, E. E.
, p. 1267 - 1271 (1989)
It was established that the yields of a 4-allyl-4-aryl-aminopiperidines in the reaction of 4-aryliminopiperidines with allylmagnesium bromide increase significantly if the reaction is carried out in the presence of a crown ether.A number of previously unknown spiro were obtained in the cyclization of 4-allyl-4-arylaminopiperidines in the presence of sulfuric acid.
SYNTHESIS OF 4-SUBSTITUTED 1-METHYL(BENZYL)-2,5-DIMETHYL-4-R-AMINOPIPERIDINES
Kuznetsov, V. V.,Gaivoronskaya, L. A.,Romero, R. M.,Stashenko, E. E.,Zakharov, P. I.,Prostatkov, N. S.
, p. 783 - 786 (2007/10/02)
Schiff base derivatives of 1-methyl(benzyl)-2,5-dimethylpiperidin-4-ones with phenyl, α-pyridyl, benzyl, and β-hydroxyethyl substituents attached to the imine nitrogen atom react with organometallic compounds to give analogously substituted piperidine bases with methyl, allyl, phenyl, and benzyl substituents in the the 4-position.Pure individual geometric isomers of these newly synthetised compound have been isolated and their structures determined.
