113741-01-8Relevant articles and documents
(2-aminoethyl)-N hydrofluorination compd. manufacturing method
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Paragraph 0034, (2016/12/12)
PROBLEM TO BE SOLVED: To provide a method for preparing an N-(2-aminoethyl)azole compound, which is a preparation method offering short reaction time, high purification efficiency of a final product, high production efficiency and high safety because a reaction solution undergoes no heat generation or rise of liquid level caused by bubbling. SOLUTION: The method for preparing the N-(2-aminoethyl)azole compound comprises reacting an azole-based compound (A) and an ethylamine derivative (B) having a leaving group at position 2 in the presence of a base (C) in a solvent (D) so as to prepare the N-(2-aminoethyl)azole compound. Here, the ethylamine derivative (B) having the leaving group at position 2 is fed to the reaction system in portions while the reaction system is maintained at 50-200°C. COPYRIGHT: (C)2010,JPOandINPIT
CINNAMIC ACID AMIDE DERIVATIVE
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Paragraph 0060; 0072, (2015/11/24)
The present invention provides a cinnamic acid amide derivative having an excellent analgesic action. The cinnamic acid amide derivative of the present invention is a compound showing excellent analgesic actions to not only a nociceptive pain model animal but also a neuropathic pain model animal, which is very useful as an agent for treating various pain diseases showing acute or chronic pains or neuropathic pains.
Benzoxazole carboxamides for treating CINV and IBS-D
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Page/Page column 6, (2008/06/13)
Compounds of formulae I and II: are disclosed as 5-HT3 inhibitors. Those compounds that exhibit central activity are useful in treating CINV; those that inhibit peripheral receptors are useful to treat IBS-D.