113786-33-7

Basic information

• Product Name: B 19036
• Synonyms: 10-Carboxy-3,6,9-tris(carboxymethyl)-13-phenyl-12-oxa-3,6,9-triazatridecanoic acid;4-Carboxy-5,8,11-tris(carboxymethyl)-1-phenyl-2-oxa-5,8,11-triazatridecan-13-oic acid;B 19036
• CAS NO: 113786-33-7
• Molecular Formula: C22H31N3O11
• Molecular Weight: 513.49504
• Mol File: 113786-33-7.mol

Chemical Properties

• Appearance: /
• Density: 1.446
• CAS DataBase Reference: B 19036(CAS DataBase Reference)
• NIST Chemistry Reference: B 19036(113786-33-7)
• EPA Substance Registry System: B 19036(113786-33-7)

Safety Data

• Hazardous Substances Data: 113786-33-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
B 19036 is used as an anti-cancer agent for its ability to inhibit the growth and proliferation of cancer cells by targeting CDK8 and CDK19, enzymes involved in gene transcription regulation and cell cycle progression.
Used in Inflammatory Disorders Treatment:
B 19036 is used as an anti-inflammatory agent for its potential role in modulating the inflammatory response by affecting the enzymes that play a part in inflammation pathways.
Used in Cardiovascular Disease Treatment:
B 19036 is used as a therapeutic agent for cardiovascular diseases, leveraging its influence on cellular processes that may be implicated in the pathogenesis of such conditions. Further research is required to explore its full potential in this application area.

Upstream product

• 79-08-3 bromoacetic acid 
• 790633-35-1 N-[2-[(2-aminoethyl)amino]ethyl]-O-(phenylmethyl)serine 
• 79-11-8 chloroacetic acid 

Downstream Products

• 557762-94-4 [Eu(4-carboxy-5,8-11-tris(carboxymethyl)-1-phenyl-2-oxa-5,8,11-triazatridecan-13-oic acid-5H)]^(2-) 
• 172504-22-2 Gd(4-carboxyl-5,6,11-tris(carboxymethyl)-1-phenyl-2-oxa-5,8,11-triazatridecane-13-oic acid^(5-))^(2-) 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF GADOBENATE DIMEGLUMINE COMPLEX IN A SOLID FORM

The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given temperature and concentration. The present invention is particularly advantageous for the industrial scale as the solid form may be obtained by employing water as a solvent, which is a non-toxic solvent, easy to handle and basically not requiring troublesome health or safety precautions.

PROCESS FOR THE PURIFICATION OF POLYAMINOCARBOXYLATES

The present invention relates to an improved process for the purification of polyaminocarboxylates such as DOTA, DTPA, DO3A-butrol, BOPTA.

Process for the preparation of contrast agents

The present invention refers to a process for preparing a compound of formula (I) through a carboxymethylation reaction occurring in the presence of a suitable alkylating agent and of a base, without the need of monitoring the pH of the reaction environment. The compound of formula (I) is a useful intermediate in the preparation of diagnostic contrast agents for MRI techniques.

A PROCESS FOR THE PREPARATION OF 4-CARBOXY- 5,8,11- TRIS(CARBOXYMETHYL)- 1-PHENYL- 2-OXA- 5,8,11- TRIAZATRIDECAN- 13-OIC ACID

A novel process for the preparation of 2-chloro-3-(phenylmethoxy)propionic acid potassium salt (I)