Design, synthesis, and evaluation of a novel bridged nucleic acid, 2′,5′-BNAON, with S-type sugar conformation fixed by N-O linkage
We designed a novel 2′-O,5′-N bridged nucleic acid, 2′,5′-BNAON, whose sugar puckering was fixed to S-type conformation by an N-O linkage. A dimer unit formed from 2′,5′-BNAON-U and thymidine was synthesized via a coupling reaction b