113852-38-3

Basic information

• Product Name: ({[(2S)-1-hydroxy-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propan-2-yl]oxy}methyl)phosphonic acid
• Synonyms: Phosphonic acid, ((2-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy)methyl)-, (S)-; Phosphonic acid, [[2-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-, (S)-
• CAS NO: 113852-38-3
• Molecular Formula: C₉H₁₅N₂O₇P
• Molecular Weight: 294.1984
• Mol File: 113852-38-3.mol

Chemical Properties

• Density: 1.533g/cm³
• Refractive Index: 1.556
• CAS DataBase Reference: ({[(2S)-1-hydroxy-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propan-2-yl]oxy}methyl)phosphonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: ({[(2S)-1-hydroxy-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propan-2-yl]oxy}methyl)phosphonic acid(113852-38-3)
• EPA Substance Registry System: ({[(2S)-1-hydroxy-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propan-2-yl]oxy}methyl)phosphonic acid(113852-38-3)

Safety Data

• Hazardous Substances Data: 113852-38-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
([(2S)-1-hydroxy-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propan-2-yl]oxymethyl)phosphonic acid is used as a key intermediate in the synthesis of new drugs, particularly those targeting specific biological pathways or conditions. Its unique structure allows for the development of innovative pharmaceutical agents with enhanced efficacy and selectivity.
Used as a Chelating Agent:
In various industrial processes, ([(2S)-1-hydroxy-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propan-2-yl]oxymethyl)phosphonic acid serves as an effective chelating agent. It can bind to metal ions, facilitating their separation, purification, or stabilization in different chemical reactions and processes.
Used in Material Science:
([(2S)-1-hydroxy-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propan-2-yl]oxymethyl)phosphonic acid is utilized in the development of novel materials, such as polymers, coatings, or composites, due to its ability to form stable bonds and complexes with other molecules. This contributes to the creation of materials with improved properties or new functionalities.

Upstream product

• 913274-73-4 (R)-1-{2-[(diisopropoxyphosphoryl)methoxy]-3-hydroxypropyl}-4-methoxy-5-methylpyrimidin-2(1H)-one 
• 25902-89-0 4-methoxy-5-methyl-pyrimidin-2(1H)-one 
• 913274-89-2 (S)-1-{2-[(diisopropoxyphosphoryl)methoxy]-3-hydroxypropyl}thymine 
• 897931-57-6 (S)-1-{2-[(diisopropoxyphosphoryl)methoxy]-3-(trityloxy)propyl}-4-methoxy-5-methylpyrimidin-2(1H)-one 
• 913274-87-0 (S)-1-{2-[(diisopropoxyphosphoryl)methoxy]-3-(trityloxy)propyl}thymine 
• 897931-55-4 (S)-1-[2-hydroxy-3-(trityloxy)propyl]-4-methoxy-5-methylpyrimidin-2(1H)-one 
• 913274-67-6 (R)-1-{2-[(diisopropoxyphosphoryl)methoxy]-3-(trityloxy)propyl}-4-methoxy-5-methylpyrimidin-2(1H)-one 
• 913274-62-1 (R)-1-[2-hydroxy-3-(trityloxy)propyl]-4-methoxy-5-methylpyrimidin-2(1H)-one 

Relevant articles and documents

Simple transformation of thymine 1-[3-hydroxy-2-(phosphonomethoxy)propyl] derivatives to their 1-[3-fluoro-2-(phosphonomethoxy)propyl] counterparts

A novel method of transformation of HOCH2 group to FCH 2 was successfully applied to the preparation of fluorine-containing pyrimidine acyclic nucleoside phosphonates (FPMP compounds) such as (S)- and (R)-1-[3-fluoro-2-(phosphonometh