- Tungstate-Catalyzed Oxidation of Tetrahydroquinolines with Hydrogen Peroxide: A Novel Method for the Synthesis of Cyclic Hydroxamic Acids
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The sodium tungstate catalyzed oxidation of 1,2,3,4-tetrahydroquinolines (1) with 30percent aqueous hydrogen peroxide solution in methanol gives 1-hydroxy-3,4-dihydroquinolin-2(1H)-ones (2), which are important biologically active compounds, in good to excellent yields.The cyclic hydroxamic acid 7 is also obtained in good yield.Since reduction of 2 thus obtained gives 3,4-dihydroquinolin-2(1H)-ones (4), the present reaction provides a convenient method for synthesis of 4 from 1.
- Murahashi, Shun-Ichi,Oda, Tetsuya,Sugahara, Toshiaki,Masui, Yoshiyuki
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