- A NOVEL ROUTE TO α,β-UNSATURATED ESTERS VIA A REFORMATSKY-TYPE REACTION USING SODIUM TELLURIDE
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Sodium telluride, prepared by heating tellurium and sodium hydride in a 1:2 molar ratio in dry N,N-dimethylformamide, readily debrominates a bromoacetic ester at low temperatures to generate an enolate anion, which undergoes a Reformatsky-type reaction with various non-enolizable aldehydes to give the corresponding α,β-unsaturated esters in good to moderate yields.Ketones remain almost unaffected under the same conditions.
- Suzuki, Hitomi,Inouye, Masahiko
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p. 403 - 406
(2007/10/02)
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