ATP competitive inhibitors of d-alanine-d-alanine ligase based on protein kinase inhibitor scaffolds
d-Alanine-d-alanine ligase (DDl) is an essential enzyme in bacterial cell wall biosynthesis and an important target for developing new antibiotics. Here, we describe a new approach to identify new inhibitor scaffolds for DDl based on similarity in the ATP
Triola, Gemma,Wetzel, Stefan,Ellinger, Bernhard,Koch, Marcus A.,Huebel, Katja,Rauh, Daniel,Waldmann, Herbert
experimental part
p. 1079 - 1087
(2009/08/15)
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