- WNT PATHWAY MODULATORS
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The present invention relates to dihydropyrazolo[l,5-a]pyrimidine compounds of formula I, defined herein, as WNT pathways modulators, processes for making them, and pharmaceutical compositions comprising them. Methods of treatment of conditions mediated by WNT pathway signalling including cancer, fibrosis, stem cell and diabetic retinopathy, rheumatoid arthritis, psoriasis and myocardial infarction, comprising the compounds of formula I are also provided.
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Paragraph 0251; 0252; 0277; 0278
(2015/07/07)
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- PALLADIUM-CATALYZED CROSS-COUPLING OF PHENYLBORONIC ACID WITH HETEROCYCLIC AROMATIC HALIDES
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The coupling reaction of bromo- and iodopyridines 1 with phenylboronic acid (2a) by Pd(Ph3P)4 provides a convenient route to phenylpyridines, even when electrodonating or - withdrawing substituents are present.The method is also successful for the preparation of other phenylated N-containing heterocycles 5 as phenylquinolines and -pyridines.
- Stavenuiter, Johannes,Hamzink, Martin,Hulst, Rob van der,Zomer, Gijsbert,Westra, Gerard,Kriek, Erik
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p. 2711 - 2716
(2007/10/02)
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