A facile one-pot transformation of baylis-hillman adducts into unsymmetrical disubstituted maleimide and maleic anhydride frameworks: A facile synthesis of himanimide A
Unsymmetrical, disubstituted maleimide and maleic anhydride frameworks have been accessed from Baylis-Hillman adducts in an operationally simple three-step (FriedelCrafts reaction, selective hydrolysis and cyclization), one-pot strategy. This strategy has been successfully extended to the synthesis of a representative bioactive compound, himanimide A (see scheme). (Chemical Equation Representation).
DABCO CATALYZED COUPLING OF α-KETO ESTERS WITH ACRYLONITRILE AND METHYL ACRYLATE
Coupling of acrylonitrile to α-keto esters is readily achieved using 1,4-diazabicyclo(2.2.2)-octane(DABCO) as a catalyst to produce 2-(1-carboalkoxy-1-hydroxyalkyl)acrylonitriles in good yields.Similar reaction with methyl acrylate produces the corresponding 2-substituted acrylates.
Basavaiah, D.,Bharathi, T. K.,Gowriswari, V. V. L.
p. 4351 - 4352
(2007/10/02)
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