- Novel preparation of chiral α-amino acids using the Mitsunobu-Tsunoda reaction
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An efficient synthesis of racemic or optically active α-amino acids by modified-Mitsunobu alkylation of a racemic or chiral glycine template from alcohols was developed. Libraries of amino acids were prepared in moderate to good yield with good to high enantioselectivity. This simple method widens the scope for preparation of structurally diverse amino acids.
- Noisier, Anais F. M.,Harris, Craig S.,Brimble, Margaret A.
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supporting information
p. 7744 - 7746
(2013/09/02)
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- NOVEL CYCLIC BORONATE INHIBITORS OF HCV REPLICATION
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Compounds of formula (I) or a salt thereof are provided; wherein R1, R2, R3, R4, R6, R8, R20, R30, Y, Z and n are as defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicaments for treating viral infection, especially HCV infection are also disclosed. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
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Page/Page column 74; 76
(2009/05/29)
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