114119-90-3Relevant articles and documents
A new facile one-pot preparation of pentafluorophenyl (Pfp) and 3,4-dihydro-4-oxo-1,2,3-benzotriazine-3-yl (Dhbt) esters of Fmoc amino acids
Jacobsen, Mogens Havsteen,Buchardt, Ole,Engdahl, Tom,Holm, Arne
, p. 6199 - 6202 (2007/10/02)
A new one-pot procedure for the preparation of pentafluorophenyl and 3,4-dihydro-4-oxo-1,2,3-benzotriazine-3-yl esters of Nα-9-fluorenylmethyloxycarbonyl amino acids bearing no side chain protecting groups is described. The method gives the desired activated esters in high yield and purity without use of the highly allergenic DCC.
Peptide Synthesis. Part 12. 3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl Esters of Fluorenylmethoxycarbonyl Amino Acids as Self-indicating Reagents for Solid Phase Peptide Synthesis
Atherton, Eric,Holder, Jill L.,Meldal, Morten,Sheppard, Robert C.,Valerio, Robert M.
, p. 2887 - 2894 (2007/10/02)
The preparation and characterisation of 3,4-dihydro-4-oxo-1,2,3-benzotriazinyl esters (1) of Fmocamino acids and their use in solid phase peptide synthesis is described.Ionisation of the liberated hydroxy component (2) by the starting resin-bound amine pr