114132-26-2

Basic information

• Product Name: CYCLOPROPYLMETHANESULFONYL CHLORIDE
• Synonyms: CYCLOPROPYLMETHANESULFONYL CHLORIDE;[(Chlorosulphonyl)methyl]cyclopropane;Cyclopropylmethanesulphonyl chloride;Cyclopropanemethanesulfonyl chloride
• CAS NO: 114132-26-2
• Molecular Formula: C₄H₇ClO₂S
• Molecular Weight: 154.62
• Mol File: 114132-26-2.mol

Chemical Properties

• Boiling Point: 224.143 °C at 760 mmHg
• Flash Point: 89.359 °C
• Appearance: /
• Density: 1.449 g/cm³
• CAS DataBase Reference: CYCLOPROPYLMETHANESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOPROPYLMETHANESULFONYL CHLORIDE(114132-26-2)
• EPA Substance Registry System: CYCLOPROPYLMETHANESULFONYL CHLORIDE(114132-26-2)

Safety Data

• Hazardous Substances Data: 114132-26-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Cyclopropylmethanesulfonyl Chloride is used as a synthetic reagent for the discovery of novel aminotetralines and aminochromanes. These compounds have been identified as selective and competitive inhibitors of the glycine transporter 1 (GlyT1). GlyT1 inhibitors have potential therapeutic applications in the treatment of various neurological disorders, such as schizophrenia, major depressive disorder, and chronic pain.
The use of CMS-Cl in the synthesis of these inhibitors is due to its ability to form stable carbocations, which can be utilized in the formation of the desired aminotetralines and aminochromanes. This makes CMS-Cl a valuable tool in the development of new and potentially more effective treatments for a range of neurological conditions.

Downstream Products

• 445305-93-1 cyclopropylmethanesulfonamide 
• 1436387-74-4 tert-butyl 1-benzyl-7-((cyclopropylmethylsulfonamido)methyl)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate 
• 338457-43-5 cyclopropylmethane-sulphonic acid 5-(2,4-diamino-pyrimidin-5-ylmethyl)-3-ethoxy-2-iodo-phenyl ester 

Relevant articles and documents

Substituted heteroaryl compounds and composition thereof, and applicaitons of compounds and composition

The invention provides substituted heteroaryl compounds and a composition thereof, and applicaitons of the compounds and the composition. The compounds are compounds represented by the formula (I) or the formula (II) or stereoisomers, tautomers, nitrogen oxides, solvates, metabolites, pharmaceutically acceptable salts or prodrugs of the compounds represented by the formula (I) or the formula (II). The invention also provides the pharmaceutical composition comprising the compounds; the compounds and the pharmaceutical composition can adjust the activity of protein kinase, and are used for prevention, processing, treatment and remission of diseases or disorders mediated by the protein kinase.

SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE

The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof. They are useful in preventing, managing, treating or lessening the severity of a protein kinase-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of protein kinase-mediated disease.