114199-18-7

Basic information

• Product Name: 2-amino-9-[(2-hydroxyethoxy)methyl]-7-methyl-7H-purin-9-ium-6-olate
• CAS NO: 114199-18-7
• Molecular Formula: C₉H₁₃N₅O₃
• Molecular Weight: 239.2312
• Mol File: 114199-18-7.mol

Chemical Properties

• CAS DataBase Reference: 2-amino-9-[(2-hydroxyethoxy)methyl]-7-methyl-7H-purin-9-ium-6-olate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-9-[(2-hydroxyethoxy)methyl]-7-methyl-7H-purin-9-ium-6-olate(114199-18-7)
• EPA Substance Registry System: 2-amino-9-[(2-hydroxyethoxy)methyl]-7-methyl-7H-purin-9-ium-6-olate(114199-18-7)

Safety Data

• Hazardous Substances Data: 114199-18-7(Hazardous Substances Data)

Upstream product

• 59277-89-3 acycloguanosine 
• 77-78-1 dimethyl sulfate 

Relevant articles and documents

Synthesis and Antiviral Activity of Novel N-Substituted Derivatives of Acyclovir

Novel N-substituted derivatives of acyclovir (1a) were synthesized and evaluated for their antiviral, antimetabolic, and antitumor cell properties in vitro.Monomethylation of 1a at positions 1, 7, and N-2 gave compounds 2-4, respectively.When positions 1 and N-2 were linked together by an isopreno group, the tricyclic 9--1,N-2-isopropenoquanine (5) was obtained.Compound 5 was then further methylated at positions N-2 and 7 to give 6 and 7, respectively.None of the new acyclovir derivatives showed any appreciable antimetabolic or antitumor cell activity.However, compounds 2 and 5 exhibited a marked antiherpetic activity.Their activity spectrum was similar to that of acyclovir, and their selectivity as inhibitors of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) was at least as great as, if not greater than, that of acylclovir.