1142079-64-8

Basic information

• Product Name: [1,1'-Biphenyl]-4-carboxaMide, N-[(3S)-2-oxo-3-oxetanyl]-
• Synonyms: [1,1'-Biphenyl]-4-carboxaMide, N-[(3S)-2-oxo-3-oxetanyl]-;N-[(3S)-2-oxooxetan-3-yl]-4-phenylbenzamide
• CAS NO: 1142079-64-8
• Molecular Formula: C16H13NO3
• Molecular Weight: 267.27932
• Mol File: 1142079-64-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [1,1'-Biphenyl]-4-carboxaMide, N-[(3S)-2-oxo-3-oxetanyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: [1,1'-Biphenyl]-4-carboxaMide, N-[(3S)-2-oxo-3-oxetanyl]-(1142079-64-8)
• EPA Substance Registry System: [1,1'-Biphenyl]-4-carboxaMide, N-[(3S)-2-oxo-3-oxetanyl]-(1142079-64-8)

Safety Data

• Hazardous Substances Data: 1142079-64-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Applications:
[1,1'-Biphenyl]-4-carboxamide, N-[(3S)-2-oxo-3-oxetanyl]is used as a potential pharmaceutical compound for its structural features and biological activity. [1,1'-Biphenyl]-4-carboxamide, N-[(3S)-2-oxo-3-oxetanyl]-'s oxetane ring has been studied for its potential applications in drug development, making it a candidate for further research and testing.
Used in Chemical Research:
[1,1'-Biphenyl]-4-carboxamide, N-[(3S)-2-oxo-3-oxetanyl]is used as a subject of study in chemical research for its synthesis and characterization. Understanding the properties and potential applications of this compound could lead to the development of new drugs or materials with specific characteristics.
Used in Material Science:
[1,1'-Biphenyl]-4-carboxamide, N-[(3S)-2-oxo-3-oxetanyl]may be used as a component in the development of new materials with unique properties. Its structural features, including the biphenyl derivative and oxetane ring, could contribute to the creation of innovative materials for various industries.

Upstream product

• 14002-51-8 4-biphenyl-carboxylic acid chloride 
• 112839-95-9 (S)-3-amino-2-oxetanone p-toluenesulfonic acid salt 

Relevant articles and documents

Compositions and methods of inhibiting N-acylethanolamine-hydrolyzing acid amidase

Compounds and pharmaceutical compositions are contemplated that inhibit N-acyl-ethanolamine-hydrolyzing acid amidase (NAAA) to so increase the concentration of the substrate of NAAA, palmitoylethanolamide (PEA). NAAA inhibition is contemplated to be effec

Synthesis and structure - Activity relationships of N -(2-Oxo-3-oxetanyl) amides as N -acylethanolamine-hydrolyzing acid amidase inhibitors

The fatty acid ethanolamides (FAEs) are a family of bioactive lipid mediators that include the endogenous agonist of peroxisome proliferator- activated receptor-α, palmitoylethanolamide (PEA). FAEs are hydrolyzed intracellularly by either fatty acid amide hydrolase or N-acylethanolamine- hydrolyzing acid amidase (NAAA). Selective inhibition of NAAA by (S)-N-(2-oxo-3-oxetanyl)-3-phenylpropionamide [(S)-OOPP, 7a] prevents PEA degradation in mouse leukocytes and attenuates responses to proinflammatory stimuli. Starting from the structure of 7a, a series of β-lactones was prepared and tested on recombinant rat NAAA to explore structure-activity relationships (SARs) for this class of inhibitors and improve their in vitro potency. Following the hypothesis that these compounds inhibit NAAA by acylation of the catalytic cysteine, we identified several requirements for recognition at the active site and obtained new potent inhibitors. In particular, (S)-N-(2-oxo-3-oxetanyl)biphenyl-4-carboxamide (7h) was more potent than 7a at inhibiting recombinant rat NAAA activity (7a, IC50 = 420 nM; 7h, IC50 = 115 nM) in vitro and at reducing carrageenan-induced leukocyte infiltration in vivo.