- Barbituric acid derivatives with antimetastatic and antitumor activity
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The invention is directed to barbituric acid derivatives having inhibitory activity for matrix maetalloproteases comprised of formula (I): pharmaceutical compositions thereof, processes for preparing the derivatives, and methods for treating diseases associated with elevated or uncontrolled levels of matrix metalloprotease activity, e.g., cancer, specifically tumor progression and tumor metastasis, inflammation, or as a method of contraception.
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Page column 13
(2010/01/21)
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- Scope of Organic Synthetic Reactions. Multivariate Methods for Exploring the Reaction Space. An Example with the Willgerodt-Kindler Reaction.
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New principles are presented by which the scope and limitations of synthetic reactions can be determined when substrates, reagents and solvents are allowed to vary sumaltaneously.The strategies are based on multivariate statistical methods: (a) Characteri
- Carlson, Rolf,Lundstedt, Torbjoern
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p. 164 - 173
(2007/10/02)
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