- Catalytic Transfer Hydrogenation of Arenes and Heteroarenes
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Transfer hydrogenation reactions are of great interest to reduce diverse molecules under mild reaction conditions. To date, this type of reaction has only been successfully applied to alkenes, alkynes and polarized unsaturated compounds such as ketones, imines, pyridines, etc. The reduction of benzene derivatives by transfer hydrogenation has never been described, which is likely due to the high energy barrier required to dearomatize these compounds. In this context, we have developed a catalytic transfer hydrogenation reaction for the reduction of benzene derivatives and heteroarenes to form complex 3-dimensional scaffolds bearing various functional groups at room temperature without needing compressed hydrogen gas.
- Gelis, Coralie,Heusler, Arne,Nairoukh, Zackaria,Glorius, Frank
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supporting information
p. 14090 - 14094
(2020/10/19)
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- Regioselective Iridium-Catalyzed Asymmetric Monohydrogenation of 1,4-Dienes
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A highly efficient regio- and enantioselective monohydrogenation of 1,4-dienes has been realized using an iridium catalyst with a chiral N,P-ligand under mild conditions. The substrate scope was studied and included both unfunctionalized as well as functionalized substituents on the meta- or para-position. Substrates having substituents with functionalities such as silyl protected alcohols or ketals were monohydrogenated in high regioselectivity and high enantiomeric excess (up to 98% ee).
- Liu, Jianguo,Krajangsri, Suppachai,Singh, Thishana,De Seriis, Giulia,Chumnanvej, Napasawan,Wu, Haibo,Andersson, Pher G.
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p. 14470 - 14475
(2017/10/24)
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