114371-33-4

Basic information

• Product Name: 1,2-DihydrobecloMetasone Dipropopionate
• Synonyms: (11β,16β)-9-chloro-11-hydroxy-16-Methyl-17,21-bis(1-oxopropoxy)pregn-4-ene-3,20-dione;1,2-Dihydro BecloMethasone Dipropionate;1,2-DihydrobecloMetasone Dipropopionate;BecloMethason Dipropinate IMpurity L;BecloMethasone Dipropinate IMpurity L;Beclomethasone Dipropionate Impurity L
• CAS NO: 114371-33-4
• Molecular Formula: C28H39ClO7
• Molecular Weight: 523.05806
• Product Categories: Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
• Mol File: 114371-33-4.mol

Chemical Properties

• Boiling Point: 628.8±55.0 °C(Predicted)
• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Dioxane (Slightly), Methanol (Slightly)
• PKA: 13.11±0.70(Predicted)
• CAS DataBase Reference: 1,2-DihydrobecloMetasone Dipropopionate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-DihydrobecloMetasone Dipropopionate(114371-33-4)
• EPA Substance Registry System: 1,2-DihydrobecloMetasone Dipropopionate(114371-33-4)

Safety Data

• Hazardous Substances Data: 114371-33-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1,2-DihydrobecloMetasone Dipropopionate is used as an impurity in Beclomethasone Dipropionate for [application reason]. Beclomethasone Dipropionate is a potent anti-inflammatory drug used in the treatment of various respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). The presence of 1,2-DihydrobecloMetasone Dipropopionate as an impurity may affect the efficacy and safety of the drug, and therefore, it is important to monitor and control its levels during the manufacturing process.

Relevant articles and documents

Novel process for the preparation of steroidal esters

A process for the preparation of corticosteriod esters of the formula STR1 in which ---- signifies that a double bond can be present; X is hydrogen, chlorine or fluorine; R1 is hydrogen, fluorine, chlorine or methyl, which may be either α or β; R2 is halogen, oxo or hydroxyl; or R3 is hydrogen, α-methyl or β-methyl; or R2 and X jointly form an epoxide group; R4 is an acyl group of the formula RCO, in which R is one of the following (i) an alkyl group containing 1 to 16 carbon atoms, whether straight-chained, branched or cyclic; (ii) an aralkyl group of 7 to 8 carbon atoms; (iii) a phenyl group; R5 is hydroxyl or R6 ; where R6 is hydrogen, one or two halogen atom substituents or OR7, where R7 is an acyl group of the formula R'CO in which R', which can be identical or different to R in the same molecule, is one of the following: (i) an alkyl group of 1 to 16 carbon atoms, whether straight-chained, branched or cyclic; (ii) an aralkyl group of 7 to 8 carbon atoms; or (iii) a phenyl group. which comprises esterifying a compound of the formula STR2 wherein X, R1, R3 and R5 are as defined above, and R8 is trihaloacetate, halogen or oxo, or jointly forms an epoxide group with X; at the 17-position only, or at the 17- and 21-positions when R5 in formula III is hydroxyl, the said esterification being carried out with the anhydride of the acid containing the group desired.