- Facile synthesis of polysubstituted oxazoles via A copper-catalyzed tandem oxidative cyclization
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A highly efficient synthesis of polysubstituted oxazoles was developed via a copper-catalyzed tandem oxidative cyclization. The desired products can be obtained from readily available starting materials under mild conditions. This is an attractive alterna
- Wan, Changfeng,Zhang, Jintang,Wang, Sujing,Fan, Jinmin,Wang, Zhiyong
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supporting information; experimental part
p. 2338 - 2341
(2010/08/04)
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- (2-Aryl-5-methylimidazol-4-ylcarbonyl)guanidines and (2-aryl-5-methyloxazol-4-ylcarbonyl)guanidines as NHE-1 inhibitors
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A series of (2-aryl-5-methylimidazol-4-ylcarbonyl)guanidines and (2-aryl-5-methyloxazol-4-ylcarbonyl)guanidines were synthesized and evaluated as NHE-1 inhibitors. The structure-activity relationships well matched those of furan derivatives, which were previously investigated. The (2,5-disubstituted)phenyl compounds showed better activities than the other analogues in both imidazole and oxazole compounds. Especially, 2-(2,5-dichlorophenyl)imidazole 52, and 2-(2-methoxy-5-chlorophenyl)imidazole 54 compounds exhibited potent cardioprotective efficacy both in vitro and in vivo as well as high NHE-1 inhibitory activities.
- Lee, Sunkyung,Yi, Kyu Yang,Youn, Sung Jun,Lee, Byung Ho,Yoo, Sung-eun
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scheme or table
p. 1329 - 1331
(2009/10/02)
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