- COMPOUND HAVING BENZO SEVEN-MEMBERED RING STRUCTURE, PREPARATION METHOD THEREFOR, AND USE THEREOF
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The present invention relates to a compound having a benzo seven-membered ring structure, and a preparation method therefor, and use thereof. The compound has a structure as represented by formula (I). Provided is use of the compound having the structure and prepared with the preparation method of the present invention, enantiomers, diastereomers, racemates and mixtures thereof of the compound, as well as chemically acceptable salts, crystalline hydrates and solvent mixtures of the compound and the enantiomers, diastereomers, racemates and mixtures thereof of the compound in the preparation of drugs for treating BET Bromodomain BRD4 activity or expression level related diseases.
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Paragraph 0038-0040
(2021/12/14)
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- A new air-stable Si,S-chelating ligand for Ir-catalyzed directed: Ortho C-H borylation
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A new air-stable Si,S-chelating ligand has been developed and used in an iridium-catalyzed ortho C-H borylation reaction with a broad substrate scope. This study provides the first example of using a sulfur-containing ligand in the catalytic C-H borylation process. It provides a rapid, efficient, and economical method for the preparation of organoboron compounds. This journal is
- Jiao, Jiao,Nie, Wenzheng,Song, Peidong,Li, Pengfei
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supporting information
p. 355 - 359
(2021/01/29)
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- INFLUENZA VIRUS REPLICATION INHIBITOR AND USE THEREOF
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Disclosed are a compound as shown in formula (I) as an influenza virus replication inhibitor and a preparation method therefor, a pharmaceutical composition comprising the compound and the use of the compound and pharmaceutical composition thereof in the treatment of influenza.
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Paragraph 0327-0328
(2020/08/09)
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- Thiosilane ligand and preparation method thereof as well as application of thiosilane ligand in aryl boronation catalytic reaction (by machine translation)
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The invention provides a thiosilane ligand and a preparation method thereof, and an application of the thiosilane ligand in an aryl boronation catalytic reaction. The ligand can be synthesized efficiently, the yield of the catalytic synthetic aryl boronic acid compound is high, purification is easy, the atom economy is high, and the ligand is suitable for mass synthesis in industry. (by machine translation)
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Paragraph 0108-0110
(2020/06/17)
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- FUSED PYRIDINES AS KINASE INHIBITORS
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The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
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Paragraph 0356
(2018/06/04)
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- Selenium-catalyzed C(sp3)-H acyloxylation: Application in the expedient synthesis of isobenzofuranones
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Oxidative Se-catalyzed C(sp3)-H bond acyloxylation has been used to construct a diverse array of isobenzofuranones from simple ortho-allyl benzoic acid derivatives. The synthetic procedure employs mild reaction conditions and gives high chemoselectivity enabled by an inexpensive organodiselane catalyst. The presented approach offers a new synthetic pathway toward the core structures of phthalide natural products.
- Kr?tzschmar, Felix,Kassel, Martin,Delony, Daniel,Breder, Alexander
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supporting information
p. 7030 - 7034
(2015/05/05)
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- Silyl phosphorus and nitrogen donor chelates for homogeneous ortho borylation catalysis
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Ir catalysts supported by bidentate silyl ligands that contain P- or N-donors are shown to effect ortho borylations for a range of substituted aromatics. The substrate scope is broad, and the modular ligand synthesis allows for flexible catalyst design.
- Ghaffari, Behnaz,Preshlock, Sean M.,Plattner, Donald L.,Staples, Richard J.,Maligres, Peter E.,Krska, Shane W.,Maleczka, Robert E.,Smith, Milton R.
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supporting information
p. 14345 - 14348
(2014/12/10)
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