cas 1146221-74-0, 1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 1-(1,1-dimethylethyl)-6-methyl-4-(trifluoromethyl)- | Articles data ｜lookchem

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1146221-74-0

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Facile synthesis of fluorinated pyrrolo[2,3-b]pyridines
With the purpose to synthesize novel ADAs (adenosine deaminase) and IMPDH (inosine 5′-monophosphate dehydrogenase) inhibitors the reaction of 5-amino-1-tert-butyl-1H-pyrrolo-3-carbonitrile with fluorinated 1,3-biselectrophiles was studied. An efficient an
Groth, Ulrich,Iaroshenko, Viktor O.,Wang, Yan,Wesch, Thomas
experimental part
p. 456 - 460
(2009/08/09)

Synthesis of fluorinated pyrrolo[2,3-b]pyridine and pyrrolo[2,3-d] pyrimidine nucleosides
With the purpose of synthesizing novel ADAs (adenosine deaminase) and IMPDH (inosine 5′-monophosphate dehydrogenase) inhibitors the reactions of 5-amino-1-tert-butyl-1-H-pyrrole-3-carbonitrile with fluorinated 1,3 - bielectrophiles were studied. An effici
Iaroshenko, Viktor O.,Wang, Yan,Sevenard, Dmitri V.,Volochnyuk, Dmitriy M.
experimental part
p. 1851 - 1857
(2010/01/16)

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Chemical Properties

Melting Point: 157-159 °C(Solv: isopropanol (67-63-0))
Boiling Point: 369.9±37.0 °C(Predicted)
Density: 1.22±0.1 g/cm3(Predicted)
Storage Temp.:2-8°C
PKA: 0.57±0.30(Predicted)
PSA: 41.61000
LogP: 3.99018

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