Regio- A nd Diastereoselective Copper-Catalyzed Carbometalation of Cyclopropenylsilanes
We therein report a regio- A nd diastereoselective copper-catalyzed carbometalation of enantioenriched readily available cyclopropenylsilanes as a synthetic tool to access a large family of stereodefined fully-(hexa)-substituted cyclopropanes.
Diastereo- and enantioselective preparation of cyclopropanol derivatives
The diastereoselective carbocupration reaction of alkoxy-functionalized cyclopropene derivatives, followed by a subsequent trapping of the resulting cyclopropylmetal species with an electrophilic source of oxygen (oxenoid) afforded various tetrasubstituted cyclopropanol derivatives in high diastereo- and enantiomeric ratios. Similarly, the enantioselective copper-catalyzed carbomagnesiation/oxidation (or amination) sequence on achiral nonfunctionalized cyclopropenes provided the desired cyclopropanol (and cyclopropylamine) derivatives in excellent diastereo- and enantiomeric excesses.