1-Amido-1-phenyl-3-piperidinylbutanes - CCR5 antagonists for the treatment of HIV: Part 2
Optimisation of a series of 4-piperidinyltriazoles led to the identification of compound 28a which showed good whole cell antiviral activity, excellent selectivity over the hERG ion channel and complete oral absorption.
Barber, Christopher G.,Blakemore, David C.,Chiva, Jean-Yves,Eastwood, Rachel L.,Middleton, Donald S.,Paradowski, Kerry A.
scheme or table
p. 1499 - 1503
(2009/12/07)
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