114745-26-5

Basic information

• Product Name: 5'-O-DMT-N2-Isobutyryl-2'-O-methyl-D-guanosine
• Synonyms: 5'-O-DMT-N2-Isobutyryl-2'-O-methyl-D-guanosine;DMT-2'-OMe-ibu-G;5'-O-DMT-N2-isobutyryl-2'-O-methylguanosine;Guanosine, 5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-O-Methyl-N-(2-Methyl-1-oxopropyl)-;N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydro;5'-O-DMT-N2-isobutyryl-2'-O-Methylguanosine;5'-DMT-2'-OMe-ibu-G;5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)guanosine
• CAS NO: 114745-26-5
• Molecular Formula: C₃₆H₃₉N₅O₈
• Molecular Weight: 669.731
• EINECS: 2017-001-1
• Mol File: 114745-26-5.mol

Chemical Properties

• Appearance: White to Pale Yellow/Powder
• Density: 1.35±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: Soluble in acetonitrile
• PKA: 9.16±0.20(Predicted)
• CAS DataBase Reference: 5'-O-DMT-N2-Isobutyryl-2'-O-methyl-D-guanosine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-DMT-N2-Isobutyryl-2'-O-methyl-D-guanosine(114745-26-5)
• EPA Substance Registry System: 5'-O-DMT-N2-Isobutyryl-2'-O-methyl-D-guanosine(114745-26-5)

Safety Data

• Hazardous Substances Data: 114745-26-5(Hazardous Substances Data)

Usage

Uses

Used in Biochemical and Nanotechnology Studies:
5'-O-DMT-N2-Isobutyryl-2'-O-methyl-D-guanosine is used as a key component in the preparation of synthetic RNA derivatives. These derivatives, such as native-like crosslinked duplex RNA, are essential for various biochemical and nanotechnology research applications, enabling the study of RNA structure, function, and interactions at a molecular level.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5'-O-DMT-N2-Isobutyryl-2'-O-methyl-D-guanosine is utilized for its potential therapeutic applications. Its unique structure and affinity for tissues make it a promising candidate for the development of new drugs targeting specific biological pathways or receptors.
Used in Research and Development:
5'-O-DMT-N2-Isobutyryl-2'-O-methyl-D-guanosine is also used in research and development settings to explore its potential in various scientific applications. This includes studying its interactions with biological molecules, understanding its role in cellular processes, and investigating its potential as a therapeutic agent for various diseases.

Upstream product

• 63264-29-9 N²-isobutyryl-2′-O-methylguanosine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 186581-53-3 diazomethane 
• 81246-83-5 9-(5-O-dimethoxytrityl-β-D-ribofuranosyl)-2-N-isobutyrylguanine 

Downstream Products

• 199581-46-9 Thiocarbonic acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-methoxy-tetrahydro-furan-3-yl] ester O-(3-tert-butyl-phenyl) ester 
• 198703-58-1 N-(9-{(2R,3R,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-formyl-3-methoxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide 
• 880260-29-7 C₄₂H₅₃N₅O₈Si 
• 1058150-81-4 O-(N₄,2',3'-O,O-tribenzoylcytidin-5'-yl)-O-[N₂-isobutyryl-2'-O-methyl-5'-O-(4,4'-dimethoxytrityl)guanosin-3'-yl] hydrogenophosphonate diester 
• 1355047-26-5 C₄₉H₆₂N₇O₁₀P 

Relevant articles and documents

An efficient multigram synthesis of monomers for the preparation of novel oligonucleotides containing isosteric non-phosphorous backbones

The facile preparation of two novel classes of nucleoside analogs for the inclusion as dimeric non-phosphorous containing subunits in chime fie backbones has been accomplished. The concise preparation of 3'- formylnucleosides and 5'-O-(N-methylhydroxylamino)-nucleosides is reported.

Oligo(2′-O-methylribonucleotides) and their derivatives. II. Synthesis and properties of oligo(2′-O-methylribonucleotides) modified with N-(2-hydroxyethyl)phenazinium and steroid groups at the 5′-terminus

Oligo(2′-O-methylribonucleotides) modified at the 5′-terminus with a steroid (cholesterol or testosterone) or polycyclic aromatic dye N-(2-hydroxyethyl)phenazinium residue were synthesized. It was shown that the introduction of an N-(2-hydroxyethyl)phenazinium moiety into octa(2′-O-methylribonucleotide) increased the melting temperature of the duplex with the d-target by 9°C. The steroid residue, which was attached to the 5′-position of deca(2′-O-methyluridylate) via a phosphodiester linkage, enhanced the stability of the steroid conjugate complexes with d(pA)16 and (pA)16; this effect was stronger with the cholesterol derivative (ΔTm 5 and 8°C, respectively) than with the testosterone derivative(ΔTm 1 and 4°C).