α-Methyl tryptophanylphenylalanines and their arylethylamine 'dipeptoid' analogues of the tetrapeptide cholecystokinin (30-33)
A series of N-alkyl carbamate blocked α-Me-Trp-Phe and α-Me-Trp-phenethylamides has been identified as 'dipeptoid' analogues of CCK-4 (CCK 30-33). These compounds have micromolar affinity for the type-B central CCK receptor, some of which increase the fir
Certain 2-substituted-[2-substituted-amino]-N-arylalkyl-3-[indol-3-yl]propanamides demonstrate activity as appetite suppressants. The compounds, pharmaceutical compositions, and a method of suppressing appetite are disclosed.
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(2008/06/13)
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