114781-18-9 Usage
Uses
Used in Pharmaceutical Industry:
(R)-2-AMINO-2-ETHYLOCTANOIC ACID is used as a pharmaceutical intermediate for the synthesis of various drugs and bioactive molecules. Its unique structure and chirality allow for the development of targeted therapies and medications with improved efficacy and selectivity.
Used in Medicinal Chemistry:
(R)-2-AMINO-2-ETHYLOCTANOIC ACID is used as a key component in the design and development of new drugs. Its properties can be leveraged to create novel molecular structures with potential therapeutic applications, contributing to the advancement of medicinal chemistry.
Used in Drug Development:
(R)-2-AMINO-2-ETHYLOCTANOIC ACID is utilized in the drug development process to create innovative pharmaceuticals. Its chiral nature and structural features enable the development of drugs with enhanced specificity, potentially leading to improved treatment options for various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 114781-18-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,7,8 and 1 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 114781-18:
(8*1)+(7*1)+(6*4)+(5*7)+(4*8)+(3*1)+(2*1)+(1*8)=119
119 % 10 = 9
So 114781-18-9 is a valid CAS Registry Number.
114781-18-9Relevant articles and documents
Chemo-Enzymic Synthesis of Optically Active α,α-Disubstituted α-Amino Acids
Liu, Weiguo,Ray, Paul,Benezra, Steven A.
, p. 553 - 560 (2007/10/02)
A series of α,α-disubstituted α-amino esters was chemically synthesized and then resolved through enantioselective hydrolysis catalysed by a new enzyme isolated from crude Humicola langinosa lipase.This enzyme only accepts free amino esters as substrates with neither lipase activity toward olive oil nor esterase activity toward o-nitrophenyl butyrate.It is unique in that it successfully catalyses the resolution of amino esters with two large α-alkyl groups including aliphatic, aromatic and cyclic amino esters.Examples of resolutions where the alkyl groups differ in size by as little as a single carbon atom have been demonstrated.For determination of absolute configuration, some of the optically active α,α-disubstituted amino acids were also prepared through Schoellkopf's asymmetric synthesis and the structures were verified by X-ray crystallography.A model depicting the substrate binding site of the enzyme is proposed.
