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114873-03-9

(S)-N-BOC-3-Chlorophenylalanine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 114873-03-9 Structure

  • Basic information

    1. Product Name: (S)-N-BOC-3-Chlorophenylalanine
    2. Synonyms: BOC-L-3-CHLOROPHE;BOC-L-3-CHLOROPHENYLALANINE;BOC-L-PHE(3-CL)-OH;BOC-M-CHLORO-L-PHE-OH;BOC-3-CHLORO-L-PHENYLALANINE;BOC-PHE(3-CL)-OH;BOC-PHE(M-CL)-OH;3-chloro-n-[(1,1-dimethylethoxy)carbonyl]-l-phenylalanine
    3. CAS NO:114873-03-9
    4. Molecular Formula: C14H18ClNO4
    5. Molecular Weight: 299.75
    6. EINECS: N/A
    7. Product Categories: Amino Acids;Phenylalanine analogs and other aromatic alpha amino acids;Amino Acid Derivatives;Unusual Amino Acids;Peptide;a-amino
    8. Mol File: 114873-03-9.mol

  • Chemical Properties

    1. Melting Point: 110°C
    2. Boiling Point: 452.5°Cat760mmHg
    3. Flash Point: 227.5°C
    4. Appearance: /
    5. Density: 1.245
    6. Vapor Pressure: 5.61E-09mmHg at 25°C
    7. Refractive Index: 1.538
    8. Storage Temp.: Store at 0°C
    9. Solubility: N/A
    10. PKA: 3.81±0.10(Predicted)
    11. CAS DataBase Reference: (S)-N-BOC-3-Chlorophenylalanine(CAS DataBase Reference)
    12. NIST Chemistry Reference: (S)-N-BOC-3-Chlorophenylalanine(114873-03-9)
    13. EPA Substance Registry System: (S)-N-BOC-3-Chlorophenylalanine(114873-03-9)

  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: N/A
    3. Safety Statements: 22-24/25
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 114873-03-9(Hazardous Substances Data)

114873-03-9 Usage

Chemical Properties

White powder

Check Digit Verification of cas no

The CAS Registry Mumber 114873-03-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,8,7 and 3 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 114873-03:
(8*1)+(7*1)+(6*4)+(5*8)+(4*7)+(3*3)+(2*0)+(1*3)=119
119 % 10 = 9
So 114873-03-9 is a valid CAS Registry Number.
InChI:InChI=1/C14H18ClNO4/c1-14(2,3)20-13(19)16-11(12(17)18)8-9-5-4-6-10(15)7-9/h4-7,11H,8H2,1-3H3,(H,16,19)(H,17,18)/t11-/m0/s1

114873-03-9 Well-known Company Product Price

  • Brand
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  • Detail

  • Alfa Aesar

  • (H52015)  N-Boc-3-chloro-L-phenylalanine, 95%   

  • 114873-03-9

  • 250mg

  • 176.0CNY

  • Detail

  • Alfa Aesar

  • (H52015)  N-Boc-3-chloro-L-phenylalanine, 95%   

  • 114873-03-9

  • 1g

  • 529.0CNY

  • Detail

  • Alfa Aesar

  • (H52015)  N-Boc-3-chloro-L-phenylalanine, 95%   

  • 114873-03-9

  • 5g

  • 2117.0CNY

  • Detail

114873-03-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Boc-3-chloro-L-phenylalanine

1.2 Other means of identification

Product number -
Other names BOC-PHE(M-CL)-OH

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:114873-03-9 SDS

114873-03-9Relevant articles and documents

Discovery of pyrrolopyrimidine inhibitors of Akt

Blake, James F.,Kallan, Nicholas C.,Xiao, Dengming,Xu, Rui,Bencsik, Josef R.,Skelton, Nicholas J.,Spencer, Keith L.,Mitchell, Ian S.,Woessner, Richard D.,Gloor, Susan L.,Risom, Tyler,Gross, Stefan D.,Martinson, Matthew,Morales, Tony H.,Vigers, Guy P.A.,Brandhuber, Barbara J.

scheme or table, p. 5607 - 5612 (2010/11/17)

The discovery and optimization of a series of pyrrolopyrimidine based protein kinase B (Pkb/Akt) inhibitors discovered via HTS and structure based drug design is reported. The compounds demonstrate potent inhibition of all three Akt isoforms and knockdown of phospho-PRAS40 levels in LNCaP cells and tumor xenografts.

Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design

Greenspan,Clark,Tommasi,Cowen,McQuire,Farley,Van Duzer,Goldberg,Zhou,Du,Fitt,Coppa,Fang,Macchia,Zhu,Capparelli,Goldstein,Wigg,Doughty,Bohacek,Knap

, p. 4524 - 4534 (2007/10/03)

Cathepsin B is a member of the papain superfamily of cysteine proteases and has been implicated in the pathology of numerous diseases, including arthritis and cancer. As part of an effort to identify potent, reversible inhibitors of this protease, we examined a series of dipeptidyl nitriles, starting with the previously reported Cbz-Phe-NH-CH2CN (19, IC50 = 62 μM). High-resolution X-ray crystallographic data and molecular modeling were used to optimize the P1, P2, and P3 substituents of this template. Cathepsin B is unique in its class in that it contains a carboxylate recognition site in the S2′ pocket of the active site. Inhibitor potency and selectivity were enhanced by tethering a carboxylate functionality from the carbon α to the nitrile to interact with this region of the enzyme. This resulted in the identification of compound 10, a 7 nM inhibitor of cathepsin B, with excellent selectivity over other cysteine cathepsins.

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