114883-30-6

Basic information

• Product Name: 6'-Carboxy SiMvastatin
• Synonyms: [2R-[2α,4α,4aβ,5β(2R*,4R*),6β]]-4-(2,2-DiMethyl-1-oxobutoxy)-2,3,4,4a,5,6-hexahydro-6-Methyl-5-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-2-naphthalenecarboxylic Acid;6a€-Carboxy Simvastatin
• CAS NO: 114883-30-6
• Molecular Formula: C25H36O7
• Molecular Weight: 448.54914
• Product Categories: Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Chiral Reagents, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 114883-30-6.mol

Chemical Properties

• Boiling Point: 639.3±55.0 °C(Predicted)
• Appearance: /
• Density: 1.21±0.1 g/cm3(Predicted)
• PKA: 3.87±0.70(Predicted)
• CAS DataBase Reference: 6'-Carboxy SiMvastatin(CAS DataBase Reference)
• NIST Chemistry Reference: 6'-Carboxy SiMvastatin(114883-30-6)
• EPA Substance Registry System: 6'-Carboxy SiMvastatin(114883-30-6)

Safety Data

• Hazardous Substances Data: 114883-30-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6'-Carboxy SiMvastatin is used as an antihyperlipidemic agent for the treatment of hypercholesterolemia. It works by inhibiting the enzyme HMG-CoA reductase, which is responsible for the conversion of HMG-CoA to mevalonate, a rate-limiting step in cholesterol synthesis. This inhibition leads to a decrease in cholesterol levels, reducing the risk of cardiovascular diseases such as atherosclerosis and coronary artery disease.
Additionally, 6'-Carboxy SiMvastatin has been found to have pleiotropic effects, including anti-inflammatory and antioxidant properties, which contribute to its overall cardiovascular protective effects.
Used in Research Applications:
In the field of research, 6'-Carboxy SiMvastatin is used as a tool compound to study the role of HMG-CoA reductase in various biological processes. It is also employed in the investigation of the molecular mechanisms underlying cholesterol synthesis and its regulation, as well as in the development of new therapeutic strategies for the treatment of hypercholesterolemia and related conditions.
Used in Drug Delivery Systems:
Similar to Gallotannin, 6'-Carboxy SiMvastatin can also be incorporated into drug delivery systems to enhance its bioavailability, targeting, and therapeutic efficacy. These systems may include liposomes, nanoparticles, or other advanced drug carriers designed to improve the pharmacokinetics and pharmacodynamics of the compound, allowing for more effective treatment of hypercholesterolemia and other related conditions.

Relevant articles and documents

HMG-CoA reductase inhibitors

Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) and (II): STR1

Intermediates and processes for 6-carboxy HMG-CoA reductase inhibitors

This invention discloses intermediates and a process for the preparation of 6-desmethyl-6-carboxy derivatives of lovastatin and analogs thereof at the 9-acyl side chain.