114931-01-0

Basic information

• Product Name: 4-[2-(4,4-dimethyl-2,6-dioxocyclohexylidene)hydrazino]-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide
• Synonyms: 4-[2-(4,4-dimethyl-2,6-dioxocyclohexylidene)hydrazino]-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide;4-[2-(4,4-dimethyl-2,6-dioxocyclohexylidene)hydrazinyl]-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
• CAS NO: 114931-01-0
• Molecular Formula: C₂₀H₂₃N₅O₄S
• Molecular Weight: 429.49272
• Mol File: 114931-01-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-[2-(4,4-dimethyl-2,6-dioxocyclohexylidene)hydrazino]-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-(4,4-dimethyl-2,6-dioxocyclohexylidene)hydrazino]-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide(114931-01-0)
• EPA Substance Registry System: 4-[2-(4,4-dimethyl-2,6-dioxocyclohexylidene)hydrazino]-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide(114931-01-0)

Safety Data

• Hazardous Substances Data: 114931-01-0(Hazardous Substances Data)

Upstream product

• 126-81-8 dimedone 
• 57-68-1 sulfadimesine 

Relevant articles and documents

Synthesis, spectral characterization, DNA binding, catalytic and in vitro cytotoxicity of some metal complexes

A series of 2-(4-sulfamethazine)hydrazono-5,5-dimethylcyclohexane-1,3-dione (HL) and its complexes of Co(II), Ni(II) and Cu(II) (1–3) were synthesized. Elemental measurements, FTIR, 1H NMR, 13C NMR, UV–Visible, X-ray diffraction analysis, and magnetic measurements have characterized the ligand and its complexes. By coordinating with the oxygen atom of the carbonyl group (C=O) and through the hydrazone moiety nitrogen atom (-NH-) with deprotonation, the ligand (HL) functions as a monobasic bidentate ligand. The coordination geometry of the complexes Co(II) and Ni(II) is octahedral, where the complex Cu(II) is square planar. The ligand and its complexes were determined with the optimized bond lengths, bond angles and quantum chemical parameters. The ligand and its complexes calves thymus DNA linking activity was examined through absorption spectra and viscosity measurements. Results of the evaluation of synthesized compounds against the Sections of MCF-7 and HepG-2 active tumor cells have been published in the viability assay for vinblastine and colchicine, relative to positive controls. The DPPH free radical-scavenging assay specifies the in vitro anti-oxidant function of all complexes. Finally, fungal (Candida albicans), gram-negative (Escherichia coli) and gram-positive (Staphylococcus aureus) bacteria have been investigated for the anti-microbial activities of the complexes using the disc diffusion process. Molecular docking was used to predict the binding of SARS-CoV-2 key protease in complex COVID-19 (5REA) between the ligand and breast cancer mutant (3hb5) receptor and the crystal structure.

Studies on Thin Layer Chromatographic Separation of some Sulpha Drugs

Some sulpha drugs in the form of their coupled products with 5,5-dimethylcyclohexane-1,3-dione and 4-hydroxy-2-methylthio-6-methylpyrimidine have been separated and identified. In order to achieve better separations these studies have been carried out usi