SYNTHESIS OF 21-THIOALKANOIC ACIDS OF CORTICOSTEROIDS
The 21-thioalkanoic acids of corticosteroids were obtained as a result of nucleophilic substitution in the reaction of the 21-sulfonic esters and 21-halogeno derivatives of corticosteroids with the thiolates of mercaptoalkanoic acids.The thiolates were synthesized by the action of bases on the corresponding mercaptoalkanoic acids.The 21-thioalkanoic acids of the corticosteroids were also obtained by the reaction of the 21-chloro and 21-bromo derivatives of the corticosteroids with mercaptoalkanoic acids in dipolar aprotic solvents.
Pshenichnyi, V. N.,Mikhal'chuk, A. L.,Khripach, V. A.
p. 507 - 512
(2007/10/02)
SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF 21-THIO DERIVATIVES OF CORTICOSTEROIDS
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Pshenitskii, V. N.,Mikhalchuk, A. L.,Khripach, V. A.,Kuz'mitskii, B. V.,Mzulo, N. A.,Shafranskaya, G. A.
p. 225 - 229
(2007/10/02)
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