cas 115104-28-4, (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT | Articles data ｜lookchem

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115104-28-4

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ASYMMETRIC DITHIOACETALS III: THE PREPARATION OF THE ENANTIOMERS OF 3-((((3-(2-(7-CHLOROQUINOLIN-2-YL)-(E)-ETHENYL)PHENYL)-3-DIMETHYLAMINO-3-OXOPROPYLTHIO)METHYL)THIO)PROPIONIC ACID (L-660,711) (MK-571), AN ANTAGONIST OF LEUKOTRIENE D4
The application of a novel method for the preparation of chiral dithioacetals to the synthesis of the enantiomers of L-660,711, an antagonist of leukotriene D4, is described.Reaction of 3-(t-butyldiphenylsilyloxymethyl)benzaldehyde or isophthal
Young, Robert N.,Gauthier, Jacques Yves,Therien, Michel,Zamboni, Robert
p. 967 - 978
(2007/10/02)

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Chemical Properties

Melting Point: 65-70°C
Boiling Point: 712.3°Cat760mmHg
Flash Point:384.6°C
Density: 1.327g/cm³
Solubility:Soluble in DMSO (up to 50 mg/ml).
Storage Temp.:Store at -20°C
Vapor Pressure: 2.72E-21mmHg at 25°C
PKA: 4.27±0.10(Predicted)
PSA: 121.10000
LogP: 6.47660

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