One-pot synthesis of 2,4,5-trisubstituted oxazoles from N-acyl amino acids by a combination of cyclodehydration with N,N′-diisopropylcarbodiimide and Wittig olefination
By a combination of cyclodehydration of N-acyl amino acids with N,N′-diisopropylcarbodiimide (DIC) and non-classical Wittig olefination of the resultant 5(4H)-oxazolones with Ph3PCHCN and Ph 3PCHCOOEt, 5-oxazoleacetonitriles and 5-oxazoleacetates were synthesized in one-pot in 41-85% and 57-70% yields, respectively.
Huang, Wenhua,Dong, Guangping,Mijiti, Zumureti
experimental part
p. 977 - 981
(2012/02/13)
Synthesis of 4-Arylidene--1,2-disubstituted-Δ2-imidazolin-5-ones
Addition of 2-substituted-5-oxo-4,5-dihydro-1,3-oxazoles (5-oxazolones) (3) to imines in benzene leads to the formation of 4-arylidene-Δ2-1,3-oxazolin-5-ones (8) which undergo aminolysis and subsequent cyclisation to the corresponding 4-arylidene-1,2-disubstituted-Δ2-imidazolin-5-ones (10) on heating under reflux in gl. acetic acid.
Kumar, Pradeep,Mukerjee, Arya K.
p. 416 - 418
(2007/10/02)
Reactions of 2-Substituted 5-Oxazolones with Imines Carrying a Vicinal Hydroxyl Group & Salicylaldehyde
5-Oxazolones, generated by cyclising N-acylglycines with ethyl chloroformate, react with imines carrying a vicinal hydroxyl group and also with salicylaldehyde.Unsaturated 5-oxazolone or 3-N-acylaminocoumarin is obtained depending on the type of reactants.
Kumar, Pradeep,Mukerjee, Arya K.
p. 704 - 707
(2007/10/02)
More Articles about upstream products of 115127-03-2