115199-84-3 Usage
Uses
Used in Pharmaceutical Industry:
2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE is used as an active pharmaceutical ingredient for its analgesic properties. As a selective κ-opioid agonist, it modulates the immune system and has the potential to provide pain relief by interacting with opioid and chemokine receptors.
Used in Research and Development:
In the field of scientific research, this compound can be used as a research tool to study the effects of κ-opioid agonists on the immune system and their potential role in modulating inflammatory responses. It can also be utilized to investigate the compound's interactions with various receptors and its potential applications in drug development.
Used in Drug Delivery Systems:
Similar to other active pharmaceutical ingredients, 2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE can be incorporated into drug delivery systems to improve its bioavailability, targeting, and overall therapeutic efficacy. This may involve the use of nanoparticles, liposomes, or other advanced drug delivery technologies to enhance the compound's performance in treating specific conditions.
Biological Activity
Highly potent κ agonist, 146-fold more active than U-50488 (trans-(?-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride ) in vitro .
Check Digit Verification of cas no
The CAS Registry Mumber 115199-84-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,1,9 and 9 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 115199-84:
(8*1)+(7*1)+(6*5)+(5*1)+(4*9)+(3*9)+(2*8)+(1*4)=133
133 % 10 = 3
So 115199-84-3 is a valid CAS Registry Number.
InChI:InChI=1/C21H24Cl2N2O.ClH/c1-24(21(26)14-16-9-10-18(22)19(23)13-16)20(15-25-11-5-6-12-25)17-7-3-2-4-8-17;/h2-4,7-10,13,20H,5-6,11-12,14-15H2,1H3;1H/t20-;/m1./s1
115199-84-3Relevant articles and documents
2-(3,4-Dichlorophenyl)-N-methyl-N-acetamides: The Use of Conformational Analysis in the Development of a Novel Series of Potent Opioid κ Agonists
Costello, Gerard F.,James, Roger,Shaw, John S.,Slater, Anthony M.,Stutchbury, Neil C. J.
, p. 181 - 189 (2007/10/02)
This paper describes the synthesis of a series of N-acetamides (1), methylated at C1 and/or C2 of the ethyl linking group, and their biological evaluation as opioid κ agonists.Conformational analysis of corresponding desaryl analogues 2 suggested that only those compounds capable of occupying an energy minimum close to that of the known κ agonist N-acetamide U-50488 might possess κ agonist properties.Starting from chiral amino acids, other alkyl and aryl substituents were introduced at C1 of the ethyl-linking moiety, giving compounds capable of adopting the same conformation as U-50488.The most potent of these, 2-(3,4-dichlorophenyl)-N-methyl-N-acetamide (8), was 146-fold more active than U-50488 in vitro in the mouse vas deferens model and exhibited potent naloxone-reversible analgesic effects (ED50 = 0.004 mg/kg sc) in an abdominal constriction model.
2-aminoethylamine derivatives, compositions of the same and use of said compounds in medicine
-
, (2008/06/13)
A compound of formula (I): STR1 or a salt and/or solvate thereof, wherein R represents an acyl group containing a substituted or unsubstituted carbocyclic aromatic or heterocyclic aromatic group; R1 and R2 each independently represents an alkyl, alkenyl or alkynyl group or R1 together with R2 represents a C3-6 polymethylene or alkenylene group; R3 represents hydrogen or alkyl; R4 represents hydrogen, halogen, alkyl, hydroxy, alkoxy, nitrile, nitro, amino or mono or disubstituted amino; and n represents O or an integer 1, is useful in the treatment of pain.
