115241-94-6

Basic information

• Product Name: (QUINOLINE-8-SULFONYLAMINO)-ACETIC ACID
• Synonyms: (QUINOLINE-8-SULFONYLAMINO)-ACETIC ACID;GLYCINE, N-(8-QUINOLINYLSULFONYL)-;2-[(8-QUINOLINYLSULFONYL)AMINO]ACETIC ACID
• CAS NO: 115241-94-6
• Molecular Formula: C₁₁H₁₀N₂O₄S
• Molecular Weight: 266.27
• Mol File: 115241-94-6.mol

Chemical Properties

• Melting Point: 129 °C
• Boiling Point: 537.3 °C at 760 mmHg
• Flash Point: 278.7 °C
• Appearance: /
• Density: 1.491 g/cm³
• PKA: 3.22±0.10(Predicted)
• CAS DataBase Reference: (QUINOLINE-8-SULFONYLAMINO)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (QUINOLINE-8-SULFONYLAMINO)-ACETIC ACID(115241-94-6)
• EPA Substance Registry System: (QUINOLINE-8-SULFONYLAMINO)-ACETIC ACID(115241-94-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 115241-94-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
(QUINOLINE-8-SULFONYLAMINO)-ACETIC ACID is used as a key intermediate in the synthesis of various pharmaceuticals and research chemicals. Its versatile chemical structure allows for the development of new drugs with potential therapeutic benefits.
Used in Antibacterial Agents:
In the Pharmaceutical Industry, (QUINOLINE-8-SULFONYLAMINO)-ACETIC ACID is used as an antibacterial agent due to the presence of the sulfonamide group. This group is known to inhibit bacterial growth and can be utilized in the development of new antibiotics to combat resistant strains.
Used in Diuretic Medications:
(QUINOLINE-8-SULFONYLAMINO)-ACETIC ACID is used as a diuretic agent in the Pharmaceutical Industry. The sulfonamide group can promote the excretion of water and electrolytes, helping to treat conditions such as edema and high blood pressure.
Used in Antimalarial and Antitumor Agents:
In the Pharmaceutical Industry, (QUINOLINE-8-SULFONYLAMINO)-ACETIC ACID is used as a potential antimalarial and antitumor agent. The quinoline ring has demonstrated activity against malaria parasites and tumor cells, making it a promising candidate for the development of new treatments.
Used in Drug Solubility and Pharmacokinetics:
(QUINOLINE-8-SULFONYLAMINO)-ACETIC ACID is used to improve the solubility and pharmacokinetic properties of drugs in the Pharmaceutical Industry. The acetic acid group can enhance the compound's water solubility, facilitating better absorption and distribution in the body.

Upstream product

• 18704-37-5 quinoline-8-sulfonyl chloride 

Relevant articles and documents

Identification of bidentate salicylic acid inhibitors of PTP1B

PTP1B is a master regulator in the insulin and leptin metabolic pathways. Hyper-activated PTP1B results in insulin resistance and is viewed as a key factor in the onset of type II diabetes and obesity. Moreover, inhibition of PTP1B expression in cancer cells dramatically inhibits cell growth in vitro and in vivo. Herein, we report the computationally guided optimization of a salicylic acid-based PTP1B inhibitor 6, identifying new and more potent bidentate PTP1B inhibitors, such as 20h, which exhibited a > 4-fold improvement in activity. In CHO-IR cells, 20f, 20h, and 20j suppressed PTP1B activity and restored insulin receptor phosphorylation levels. Notably, 20f, which displayed a 5-fold selectivity for PTP1B over the closely related PTPσ protein, showed no inhibition of PTP-LAR, PRL2 A/S, MKPX, or papain. Finally, 20i and 20j displayed nanomolar inhibition of PTPσ, representing interesting lead compounds for further investigation.