- Palladium-catalysed direct regioselective C5-arylation of a thiophene bearing a cyclopropyl ketone group at C2
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A thiophene bearing a cyclopropyl ketone group at C2 was successfully employed in palladium-catalysed direct arylation. The reaction proceeds regioselectively at C5 without decomposition of the cyclopropyl ketone substituent. These couplings were performed employing as little as 0.5 mol% of ligand-free Pd(OAc)2 catalyst with electron-deficient aryl bromides. A wide variety of functional groups on the aryl bromide such as nitrile, nitro, acetyl, formyl, benzoyl, ester, trifluoromethyl, fluoro or methoxy was tolerated. 2013 Elsevier Science. All rights reserved.
- Beladhria, Anissa,Gottumukkala, Aditya L.,Youssef, Chiraz,Bheeter, Charles Beromeo,Ben Ammar, Hamed,Ben Salem, Ridha,Doucet, Henri
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p. 119 - 122
(2013/09/02)
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